ArticleWorld journal of gastroenterology2012
Post-cholecystectomy symptoms were caused by persistence of a functional gastrointestinal disorder.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05745077 (Using Data to Achieve Surgical Health Equity in the Community), which is not on this map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Data to Achieve Surgical Health Equity in the Community
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Laparoscopic cholecystectomy versus conservative management for adults with uncomplicated symptomatic gallstones: the C-GALL RCT.Health technology assessment (Winchester, England) · 2024Trial
- Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial.BMJ (Clinical research ed.) · 2023Trial
- Trial
- Gallstone disease: on whom we should operate and on whom we do operate-an Italian snapshot.Updates in surgery · 2026Article
- Association of cholecystectomy with short-term and long-term risks of depression and suicide.Scientific reports · 2025Article
- Demography, Spectrum, and Characteristics of Symptoms Associated With Post-operative Relief After Cholecystectomy.Cureus · 2023Article
- The Symptomatic Outcomes of Cholecystectomy for Gallstones.Journal of clinical medicine · 2023Review
- Tailoring diagnosis and treatment in symptomatic gallstone disease.The British journal of surgery · 2022Review
- Dyspepsia and Gut Microbiota in Female Patients with Postcholecystectomy Syndrome.International journal of women's health · 2022Article
- Article
- Article
- Etiologies of Long-Term Postcholecystectomy Symptoms: A Systematic Review.Gastroenterology research and practice · 2019Review
- Which Abdominal Symptoms are Associated with Clinical Events in a Population Unaware of Their Gallstones? a Cohort Study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
- Consistency of patient-reported outcomes after cholecystectomy and their implications on current surgical practice: a prospective multicenter cohort study.Surgical endoscopy · 2017Article
- Episodic Abdominal Pain Characteristics Are Not Associated with Clinically Relevant Improvement of Health Status After Cholecystectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
- How Do Quality-of-Life and Gastrointestinal Symptoms Differ Between Post-cholecystectomy Patients and the Background Population?World journal of surgery · 2016Article
- Long-term follow-up of non-operated patients with symptomatic gallbladder stones: a retrospective study evaluating the role of Hepatobiliary scanning.BMC gastroenterology · 2015Article
- Article
- Natural history of acalculous biliary symptoms.Annals of the Royal College of Surgeons of England · 2013Article
- Post-cholecystectomy syndrome: A new look at an old problem.Journal of minimal access surgeryArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo classify gallstone disease as a basis for assessment of post-cholecystectomy symptoms.
methodsOne hundred and fifty three patients with a clinical and ultrasonographic diagnosis of gallstones filled out a structured questionnaire on abdominal pain symptoms and functional gastrointestinal disorder (FGID) before and at six months after cholecystectomy. Symptom frequency groups (SFG) were categorized according to frequency of pain attacks. According to certain pain characteristics in gallstone patients, a gallstone symptom score was accorded on a scale from one to ten. A visual analogue scale was used to quantify pain. Operative specimens were examined for size and magnitude of stone contents as well as presence of bacteria. Follow-up took place after six months with either a consultation or via a mailed questionnaire. Results were compared with those obtained pre-operatively to describe and analyze symptomatic outcome.
resultsSFG groups were categorized as severe (24.2%), moderate (38.6%), and mild (22.2%) attack frequency, and a chronic pain condition (15%). Pain was cured or improved in about 90% of patients and two-thirds of patients obtained complete symptom relief. Patients with the most frequent pain episodes were less likely to obtain symptom relief. FGID was present in 88% of patients pre-operatively and in 57% post-operatively (P = 0.244). Those that became asymptomatic or improved with regard to pain also had most relief from FGID (P = 0.001). No pre-operative FGID meant almost complete cure.
conclusionOnly one third of patients with FGID experienced postoperative relief, indicating that FGID was a dominant cause of post-cholecystectomy symptoms.
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