ArticleThe Journal of biological chemistry2012
Estradiol protects dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Interplay Between Keratinocytes and Fibroblasts: A Systematic Review Providing a New Angle for Understanding Skin Fibrotic Disorders.Frontiers in immunology · 2020Pooled it
- Gold@Mesoporous Polydopamine Nanocomposite Hydrogel Loaded with Estrogen for the Treatment of Skin Photoaging.International journal of nanomedicine · 2025Article
- High-molecular-weight Hyaluronan Administration Inhibits Bone Resorption and Promotes Bone Formation in Young-age Osteoporosis Rats.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024Article
- Cellular and extracellular vaginal changes following murine ovarian removal.Physiological reports · 2023Article
- Effects of Natural Antioxidants on Phospholipid and Ceramide Profiles of 3D-Cultured Skin Fibroblasts Exposed to UVA or UVB Radiation.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress.Phytotherapy research : PTR · 2020Review
- IL-23R Signaling Plays No Role in Myocardial Infarction.Scientific reports · 2018Article
- Blackcurrant Anthocyanins Increase the Levels of Collagen, Elastin, and Hyaluronic Acid in Human Skin Fibroblasts and Ovariectomized Rats.Nutrients · 2018Article
- Fibroblast and keratinocyte gene expression following exposure to the extracts of holy basil plant (Data in brief · 2018Article
- Fibroblast and keratinocyte gene expression following exposure to extracts of neem plant (Data in brief · 2018Article
- Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts.Human cell · 2018Article
- Mechanisms of skin aging induced by EGFR inhibitors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Protective effect of fermented Cyclopia intermedia against UVB-induced damage in HaCaT human keratinocytes.BMC complementary and alternative medicine · 2016Article
- Chronic UVB-irradiation actuates perpetuated dermal matrix remodeling in female mice: Protective role of estrogen.Scientific reports · 2016Article
- Synergistic effect of targeting the epidermal growth factor receptor and hyaluronan synthesis in oesophageal squamous cell carcinoma cells.British journal of pharmacology · 2015Article
- Article
- In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs.Clinical, cosmetic and investigational dermatology · 2015Article
- Skin aging modulates percutaneous drug absorption: the impact of ultraviolet irradiation and ovariectomy.Age (Dordrecht, Netherlands) · 2015Article
- Endogenous estrogen exacerbates UV-induced inflammation and photoaging in mice.The Journal of investigative dermatology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronan (HA) and versican are key components of the dermis and are responsive to ultraviolet (UV)B-induced remodeling. The aim of this study was to explore the molecular mechanisms mediating the effects of estrogen (E(2)) on HA-rich extracellular matrix during photoaging. Hairless skh-1 mice were irradiated with UVB (three times, 1 minimal erythema dose (80 mJ/cm(2)), weekly) for 10 weeks, and endogenous sex hormone production was abrogated by ovariectomy. Subcutaneous substitution of E(2) by means of controlled-release pellets caused a strong increase in the dermal HA content in both irradiated and nonirradiated skin. The increase in dermal HA correlated with induction of HA synthase HAS3 by E(2). Expression of splice variant 2 of the HA-binding proteoglycan versican was also increased by E(2). In search of candidate mediators of these effects, it was found that E(2) strongly induced the expression of epidermal growth factor (EGF) in UVB-irradiated epidermis in vivo and in keratinocytes in vitro. EGF in turn up-regulated the expression of HAS3 and versican V2 in dermal fibroblasts. HAS3 knockdown by shRNA caused inhibition of fibroblast proliferation. Furthermore, HAS3 and versican V2 induction by E(2) correlated positively with proliferation in vivo. In addition, the accumulation of inflammatory macrophages, expression of inducible cyclooxygenase 2, as well as proinflammatory monocyte chemotactic protein 1 were decreased in response to E(2) in the dermis. Collectively, these data suggest that E(2) treatment increases the amount of dermal HA and versican V2 via paracrine release of EGF, which may be implicated in the pro-proliferative and anti-inflammatory effects of E(2) during photoaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.