ArticleThe Journal of biological chemistry2012
Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Drug resistant cancer cells show increased nuclear mechanotransduction and mechanically targetable YAP-regulated vulnerability.Biomaterials · 2026Article
- Impact of fetal treatments for congenital diaphragmatic hernia on lung development.Anatomical record (Hoboken, N.J. : 2007) · 2025Review
- Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation.Developmental cell · 2024Article
- Guided Self-Assembly of ES-Derived Lung Progenitors into Biomimetic Tube Structures That Impact Cell Differentiation.Bioengineering (Basel, Switzerland) · 2021Article
- Mechanical stretch regulates the expression of specific miRNA in extracellular vesicles released from lung epithelial cells.Journal of cellular physiology · 2020Article
- Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice.American journal of respiratory cell and molecular biology · 2018Article
- Prognostic significance of the expression of HER family members in primary osteosarcoma.Oncology letters · 2018Article
- Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice.American journal of respiratory cell and molecular biology · 2016Article
- An Official American Thoracic Society Workshop Report 2015. Stem Cells and Cell Therapies in Lung Biology and Diseases.Annals of the American Thoracic Society · 2016Article
- Prognostic value of ERBB4 expression in patients with triple negative breast cancer.BMC cancer · 2016Article
- Mechanotransduction via TRPV4 regulates inflammation and differentiation in fetal mouse distal lung epithelial cells.Respiratory research · 2015Article
- Human alveolar epithelial type II cells in primary culture.Physiological reports · 2015Article
- Epithelial β1 integrin is required for lung branching morphogenesis and alveolarization.Development (Cambridge, England) · 2014Article
- Neuregulin-ErbB4 signaling in the developing lung alveolus: a brief review.Journal of cell communication and signaling · 2014Article
- Proliferative activity of liver growth factor is associated with an improvement of cigarette smoke-induced emphysema in mice.PloS one · 2014Article
- Mechanical forces in fetal lung development: opportunities for translational research.Frontiers in pediatrics · 2013Review
- TACE in perinatal mouse lung epithelial cells promotes lung saccular formation.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin α6β1-ADAM17/tumor necrosis factor-α-converting enzyme (TACE) signaling pathway.The Journal of biological chemistry · 2013Article
- Can stem cells be used to generate new lungs? Ex vivo lung bioengineering with decellularized whole lung scaffolds.Respirology (Carlton, Vic.) · 2013Review
- Development and remodeling of the vertebrate blood-gas barrier.BioMed research international · 2013Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Stretch-induced differentiation of lung fetal type II epithelial cells is mediated through EGFR (ErbB1) via release of HB-EGF and TGF-α ligands. Employing an EGFR knock-out mice model, we further investigated the role of the ErbB family of receptors in mechanotranduction during lung development. Deletion of EGFR prevented endogenous and mechanical stretch-induced type II cell differentiation via the ERK pathway, which was rescued by overexpression of a constitutively active MEK. Interestingly, the expression of ErbB4, the only ErbB receptor that EGFR co-precipitates in wild-type cells, was decreased in EGFR-deficient type II cells. Similar to EGFR, ErbB4 was activated by stretch and participated in ERK phosphorylation and type II cell differentiation. However, neuregulin (NRG) or stretch-induced ErbB4 activation were blunted in EGFR-deficient cells and not rescued after ErbB4 overexpression, suggesting that induction of ErbB4 phosphorylation is EGFR-dependent. Finally, we addressed how shedding of ligands is regulated by EGFR. In knock-out cells, TGF-α, a ligand for EGFR, was not released by stretch, while HB-EGF, a ligand for EGFR and ErbB4, was shed by stretch although to a lower magnitude than in normal cells. Release of these ligands was inhibited by blocking EGFR and ERK pathway. In conclusion, our studies show that EGFR and ErbB4 regulate stretch-induced type II cell differentiation via ERK pathway. Interactions between these two receptors are important for mechanical signals in lung fetal type II cells. These studies provide novel insights into the cell signaling mechanisms regulating ErbB family receptors in lung cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.