ArticleThe Journal of biological chemistry2012
Roles for peroxisome proliferator-activated receptor γ (PPARγ) and PPARγ coactivators 1α and 1β in regulating response of white and brown adipocytes to hypoxia.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Adipose Tissue Hypoxia in Obesity: Clinical Reappraisal of Hypoxia Hypothesis.Advances in experimental medicine and biology · 2024Review
- Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression.Adipocyte · 2019Article
- The Beige Adipocyte as a Therapy for Metabolic Diseases.International journal of molecular sciences · 2019Review
- Deferoxamine ameliorates adipocyte dysfunction by modulating iron metabolism in ob/ob mice.Endocrine connections · 2018Article
- Myocardin-related transcription factor A (MRTFA) regulates the fate of bone marrow mesenchymal stem cells and its absence in mice leads to osteopenia.Molecular metabolism · 2016Article
- Action of nicotinic acid on the reversion of hypoxic-inflammatory link on 3T3-L1 adipocytes.Lipids in health and disease · 2016Article
- Biology of Beige Adipocyte and Possible Therapy for Type 2 Diabetes and Obesity.International journal of endocrinology · 2016Review
- Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes.Cell · 2015Article
- Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program.Molecular and cellular biology · 2014Article
- The many roles of PGC-1α in muscle--recent developments.Metabolism: clinical and experimental · 2014Review
- Fra-2/AP-1 controls adipocyte differentiation and survival by regulating PPARγ and hypoxia.Cell death and differentiation · 2014Article
- Convergence of genetic and environmental factors on parvalbumin-positive interneurons in schizophrenia.Frontiers in behavioral neuroscience · 2013Review
- Thermoneutrality modifies the impact of hypoxia on lipid metabolism.American journal of physiology. Endocrinology and metabolism · 2013Article
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Authors and funding
5 authors.
Funding
Abstract
Obese white adipose tissue is hypoxic but is incapable of inducing compensatory angiogenesis. Brown adipose tissue is highly vascularized, facilitating delivery of nutrients to brown adipocytes for heat production. In this study, we investigated the mechanisms by which white and brown adipocytes respond to hypoxia. Brown adipocytes produced lower amounts of hypoxia-inducible factor 1α (HIF-1α) than white adipocytes in response to low O(2) but induced higher levels of hypoxia-associated genes. The response of white adipocytes to hypoxia required HIF-1α, but its presence alone was incapable of inducing target gene expression under normoxic conditions. In addition to the HIF-1α targets, hypoxia also induced many inflammatory genes. Exposure of white adipocytes to a peroxisome proliferator-activated receptor γ (PPARγ) ligand (troglitazone) attenuated induction of these genes but enhanced expression of the HIF-1α targets. Knockdown of PPARγ in mature white adipocytes prevented the usual robust induction of HIF-1α targets in response to hypoxia. Similarly, knockdown of PPARγ coactivator (PGC) 1β in PGC-1α-deficient brown adipocytes eliminated their response to hypoxia. These data demonstrate that the response of white adipocytes requires HIF-1α but also depends on PPARγ in white cells and the PPARγ cofactors PGC-1α and PGC-1β in brown cells.
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