ArticleThe Journal of biological chemistry2012
Impaired manganese metabolism causes mitotic misregulation.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023Review
- Manganese Stress Tolerance Depends on Yap1 and Stress-Activated MAP Kinases.International journal of molecular sciences · 2022Article
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- Effects of manganese on maturation of porcine oocytes in vitro and their subsequent embryo development after parthenogenetic activation and somatic cell nuclear transfer.The Journal of reproduction and development · 2019Article
- Intracellular Distribution of Manganese by theThe Plant cell · 2017Article
- The role of the ATP2C1 gene in Hailey-Hailey disease.Cellular and molecular life sciences : CMLS · 2017Review
- Genome Mutational and Transcriptional Hotspots Are Traps for Duplicated Genes and Sources of Adaptations.Genome biology and evolution · 2017Article
- Manganese redistribution by calcium-stimulated vesicle trafficking bypasses the need for P-type ATPase function.The Journal of biological chemistry · 2015Article
- Biochemical analysis of six genetic variants of error-prone human DNA polymerase ι involved in translesion DNA synthesis.Chemical research in toxicology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Manganese is an essential trace element, whose intracellular levels need to be carefully regulated. Mn(2+) acts as a cofactor for many enzymes and excess of Mn(2+) is toxic. Alterations in Mn(2+) homeostasis affect metabolic functions and mutations in the human Mn(2+)/Ca(2+) transporter ATP2C1 have been linked to Hailey-Hailey disease. By deletion of the yeast orthologue PMR1 we have studied the impact of Mn(2+) on cell cycle progression and show that an excess of cytosolic Mn(2+) alters S-phase transit, induces transcriptional up-regulation of cell cycle regulators, bypasses the need for S-phase cell cycle checkpoints and predisposes to genomic instability. On the other hand, we find that depletion of the Golgi Mn(2+) pool requires a functional morphology checkpoint to avoid the formation of polyploid cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.