ArticleJournal of medical microbiology2012
Genetic diversity of locus of enterocyte effacement genes of enteropathogenic Escherichia coli isolated from Peruvian children.
Article in Journal of medical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- High Burden of Vaginal Infections and Multidrug Resistance With Promising Probiotic Candidates From Cervicovaginal Microbiota in North Region, Cameroon.Probiotics and antimicrobial proteins · 2026Article
- Comparative Genomics of Atypical Enteropathogenic Escherichia coli from Kittens and Children Identifies Bacterial Factors Associated with Virulence in Kittens.Infection and immunity · 2021Article
- Association of Atypical Enteropathogenic Escherichia coli with Diarrhea and Related Mortality in Kittens.Journal of clinical microbiology · 2017Article
- Immunogenic Domains and Secondary Structure ofFrontiers in immunology · 2017Article
- Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants.Nature microbiology · 2016Article
- Adherence and virulence genes of Escherichia coli from children diarrhoea in the Brazilian Amazon.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2015Article
- Diarrheagenic Escherichia coli phylogroups are associated with antibiotic resistance and duration of diarrheal episode.TheScientificWorldJournal · 2015Article
- Enteropathogens associated with acute diarrhea in children from households with high socioeconomic level in uruguay.International journal of microbiology · 2015Article
- Genetic evaluation of Locus of enterocyte effacement pathogenicity island (LEE) in Enteropathogenic Escherichia coli isolates (EPEC).Iranian journal of microbiology · 2013Article
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Authors and funding
8 authors.
Funding
Abstract
The aim of this study was to determine the frequency and allele associations of locus of enterocyte effacement encoded esp and tir genes among 181 enteropathogenic Escherichia coli (EPEC) strains (90 diarrhoea-associated and 91 controls) isolated from Peruvian children under 18 months of age. We analysed espA, espB, espD and tir alleles by PCR-RFLP. EPEC strains were isolated with higher frequency from healthy controls (91/424, 21.7%) than from diarrhoeal samples (90/936, 9.6%) (P<0.001); 28.9% of diarrhoeal and 17.6% of control samples were typical EPEC (tEPEC). The distribution of espA alleles (alpha, beta, beta2 and gamma) and espD alleles (alpha, beta, gamma and a new variant, espD-N1) between tEPEC and atypical EPEC (aEPEC) was significantly different (P<0.05). espD-alpha was more common among acute episodes (P<0.05). espB typing resulted in five alleles (alpha, beta, gamma and two new sub-alleles, espB-alpha2 and espB-alpha3), while tir-beta and tir-gamma2 were the most common intimin receptor subtypes. Seventy-two combinations of espA, espB, espD and tir alleles were found; the most prevalent combination was espA-beta, espB-beta, espD-beta, tir-beta (34/181 strains), which was more frequent among tEPEC strains (P<0.05). Our findings indicate that there is a high degree of heterogeneity among EPEC strains isolated from Peruvian children and that aEPEC and tEPEC variants cluster.
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