ArticleProceedings of the National Academy of Sciences of the United States of America2012
Footprints of positive selection associated with a mutation (N1575Y) in the voltage-gated sodium channel of Anopheles gambiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.
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144 citing papers in PubMed.
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- High resistance of Anopheles gambiae s.L. populations to public health insecticides in Ghana: contribution of domestic and agricultural pesticide use.BMC infectious diseases · 2026Article
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- Pyrethroids resistance and distribution of kdr mutations (L1014F and N1575Y) in Anopheles gambiae s.l. along the south-north transect of Benin.Malaria journal · 2026Article
- Genomic insights into the spread and evolution of insecticide resistance variants in Anopheles gambiae s.l. from Burkina Faso.Scientific reports · 2026Article
- Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools Used in Malaria Control.Molecular ecology · 2026Article
- Comparative analysis reveals concentration-dependent and site-specific detoxification gene expression patterns in pyrethroid-resistant Anopheles gambiae s.l. from Accra, Ghana.Scientific reports · 2026Article
- Insecticide resistance dynamics inGigaByte (Hong Kong, China) · 2026Article
- Distinct Genetic Footprint of Adaptation Observed WithinResearch and reports in tropical medicine · 2026Article
- Comparative transcriptomic analysis of pyrethroid-resistant Anopheles gambiae s.l. from Ghana, reveals concentration-dependent and site-specific patterns of gene expression.Research square · 2025Article
- Standing genetic variation underlies divergence of nicotinic acetylcholine receptor subunits among cryptic species of thebioRxiv : the preprint server for biology · 2025Article
- Genomic insights into the spread and evolution of insecticide resistance in Anopheles gambiae s.l. from Burkina Faso.Research square · 2025Article
- Environmental contaminants drive insecticide resistance in Anopheles mosquitoes in Ghana.Scientific reports · 2025Article
- Identification of Novel Gene Cluster Potentially Associated with Insecticide Resistance inGenes · 2025Article
- First large-scale assessment of pyrethroid resistance in Anopheles darlingi (Diptera: Culicidae) in Brazil (2021-2024): a crucial step in informing decision-making in malaria control.Malaria journal · 2025Article
- Characterization of insecticide resistance mechanisms in the Anopheles gambiae population of Sierra Leone.Malaria journal · 2025Article
- Omics Approaches in Understanding Insecticide Resistance in Mosquito Vectors.International journal of molecular sciences · 2025Review
- Cross-Resistance to Pyrethroids and Neonicotinoids in Malaria Vectors from Vegetable Farms in the Northern Benin.Tropical medicine and infectious disease · 2024Article
- Insecticide Resistance and Target-Site MutationsGenes · 2024Article
84 more citing papers are in PubMed but not listed here.
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Abstract
Insecticide resistance is an ideal model to study the emergence and spread of adaptative variants. In the African malaria mosquito, Anopheles gambiae, this is complemented by a strong public health rationale. In this insect, resistance to pyrethroid and DDT insecticides is strongly associated with the mutations L1014F and L1014S within the para voltage-gated sodium channel (VGSC). Across much of West Africa, 1014F frequency approaches fixation. Here, we document the emergence of a mutation, N1575Y, within the linker between domains III-IV of the VGSC. In data extending over 40 kbp of the VGSC 1575Y occurs on only a single long-range haplotype, also bearing 1014F. The 1014F-1575Y haplotype was found in both M and S molecular forms of An. gambiae in West/Central African sample sites separated by up to 2,000 km. In Burkina Faso M form, 1575Y allele frequency rose significantly from 0.053 to 0.172 between 2008 and 2010. Extended haplotype homozygosity analysis of the wild-type 1575N allele showed rapid decay of linkage disequilibrium (LD), in sharp contrast to the extended LD exhibited by 1575Y. A haplotype with long-range LD and high/increasing frequency is a classical sign of strong positive selection acting on a recent mutant. 1575Y occurs ubiquitously on a 1014F haplotypic background, suggesting that the N1575Y mutation compensates for deleterious fitness effects of 1014F and/or confers additional resistance to insecticides. Haplotypic tests of association suggest the latter: The 1014F-1575Y haplotype confers a significant additive benefit above 1014F-1575N for survival to DDT (M form P = 0.03) and permethrin (S form P = 0.003).
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