ArticleAmerican journal of respiratory cell and molecular biology2012
Amphiregulin-dependent mucous cell metaplasia in a model of nonallergic lung injury.
Article in American journal of respiratory cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Fate mapping reveals a prenatal-to-neonatal wave of ILC2s with a history of Cd3g expression.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Cell Culture Differentiation and Proliferation Conditions Influence theAmerican journal of respiratory cell and molecular biology · 2024Article
- The disruptive effects of COPD exacerbation-associated factors on epithelial repair responses.Frontiers in immunology · 2024Article
- Regulation of the alveolar regenerative niche by amphiregulin-producing regulatory T cells.The Journal of experimental medicine · 2023Article
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- Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease.Mucosal immunology · 2022Article
- Inhibition of Gabrp reduces the differentiation of airway epithelial progenitor cells into goblet cells.Experimental and therapeutic medicine · 2021Article
- Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma.Frontiers in medicine · 2020Article
- BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications.American journal of respiratory and critical care medicine · 2019Article
- ICOS protects against mortality from acute lung injury through activation of IL-5Mucosal immunology · 2018Article
- GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen.Mucosal immunology · 2017Article
- EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium.Stem cells (Dayton, Ohio) · 2017Article
- Post-injury and resolution response to repetitive inhalation exposure to agricultural organic dust in mice.Safety (Basel, Switzerland) · 2017Article
- DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma.JCI insight · 2016Article
- IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
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- Ventilation-induced increases in EGFR ligand mRNA are not altered by intra-amniotic LPS or ureaplasma in preterm lambs.PloS one · 2014Article
- Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice.American journal of physiology. Lung cellular and molecular physiology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Proliferation and differentiation of the pulmonary epithelium after injury is a critical process in the defense against the external environment. Defects in this response can result in airway remodeling, such as mucus cell metaplasia (MCM), commonly seen in patients with chronic lung disease. We have previously shown that amphiregulin (AREG), a ligand to the epidermal growth factor receptor (EGFR), is induced during the repair/differentiation process elicited by naphthalene-induced lung injury. Thus, we hypothesized that AREG signaling plays an important role in epithelial proliferation and differentiation of the repairing airway. Mice deficient in AREG and lung epithelial EGFR were used to define roles for AREG-dependent EGFR signaling in airway repair and remodeling. We show that AREG and epithelial EGFR expression is dispensable to pulmonary epithelial repair after naphthalene-induced lung injury, but regulates secretory cell differentiation to a mucus-producing phenotype. We show that the pulmonary epithelium is the source of AREG, suggesting that naphthalene-induced MCM is mediated through an autocrine signaling mechanism. However, induction of MCM resulting from allergen exposure was independent of AREG. Our data demonstrate that AREG-dependent EGFR signaling in airway epithelial cells contributes to MCM in naphthalene-induced lung injury. We conclude that AREG may represent a determinant of nonallergic chronic lung diseases complicated by MCM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.