ArticleAmerican journal of respiratory cell and molecular biology2012
Rhinovirus-induced IL-1β release from bronchial epithelial cells is independent of functional P2X7.
Article in American journal of respiratory cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Neuroinflammatory Consequences of Rhinovirus Infection in Human Epithelial and Neuronal Models.Lung · 2025Article
- P2XAmerican journal of physiology. Lung cellular and molecular physiology · 2023Article
- Inflammasome signalling pathway in the regulation of inflammation - its involvement in the development and exacerbation of asthma and chronic obstructive pulmonary disease.Postepy dermatologii i alergologii · 2023Review
- Article
- Human rhinovirus serotypes induces different immune responses.Virology journal · 2021Article
- Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma.Annual review of immunology · 2021Article
- Article
- Article
- Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis.Frontiers in immunology · 2020Article
- ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis.eLife · 2019Article
- Inflammasome activation is required for human rhinovirus-induced airway inflammation in naive and allergen-sensitized mice.Mucosal immunology · 2019Article
- IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation.Respiratory research · 2018Article
- Article
- Nasal lavage VEGF and TNF-α levels during a natural cold predict asthma exacerbations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts.Particle and fibre toxicology · 2014Article
- Role of connexin/pannexin containing channels in infectious diseases.FEBS letters · 2014Review
- Influenza A exacerbates Staphylococcus aureus pneumonia by attenuating IL-1β production in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Nucleotide receptor P2RX7 stimulation enhances LPS-induced interferon-β production in murine macrophages.Journal of leukocyte biology · 2013Article
- Interaction between allergy and innate immunity: model for eosinophil regulation of epithelial cell interferon expression.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2013Article
- Virus/allergen interactions in asthma.Current allergy and asthma reports · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Airway epithelial cell defenses to viral infections are often compromised in disease or injury. Danger molecules, including ATP, are released during infection and contribute to nucleotide receptor-dependent inflammatory responses, largely through P2X(7). Although respiratory epithelium has been shown to express a variety of nucleotide receptors, the functional contribution of P2X(7) to the epithelial cell inflammatory response is unclear. We used human donor bronchial epithelial cells (BECs) and primary brushed epithelium to explore responses upon nucleotide and Toll-like receptor stimulation. P2X(7) messenger RNA and protein were observed in unprimed BECs, whereas inflammatory cytokine stimulation increased both messenger RNA and protein. Functional pore activity characteristic of P2X(7) was observed in BECs, and IL-1β was rapidly released by BECs after Toll-like receptor 3 agonist, polyinosine-polycytidylic acid, priming followed by ATP administration, although no change was observed in IL-18 release. BECs produced more IL-1β after stimulation with polyinosine-polycytidylic acid than LPS, showing a different preferential response than monocytes. In addition, blockade of nucleotide receptors with oxidized ATP significantly increased human rhinovirus (HRV) recovered 24 hours after infection in BECs, whereas 2'-3'-O-(4-benzoylbenzoyl) ATP treatment of brushed epithelial cells and respiratory cell lines nonsignificantly decreased HRV recovery. IL-1β release was detected after HRV infection in both BECs and brushed cells, but BzATP did not significantly increase IL-1β release further. BEC processing of pro-IL-1β to the mature, cleaved, 17-kD form was confirmed by Western blotting. These results support the expression of functional P2X(7) in human lung epithelium, although its role in epithelial pathogen defense is likely independent of IL-1 family cytokine processing.
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