Evidence map›Paper›PMID 22492988›Full record

Trial reportAmerican journal of respiratory and critical care medicine2012

The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury.

Mark E Mikkelsen, Jason D Christie, Paul N Lanken, Rosette C Biester, B Taylor Thompson, Scarlett L Bellamy, A Russell Localio, Ejigayehu Demissie, Ramona O Hopkins, Derek C Angus

Registry-linked trialAbstract readClinical TrialComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06501118 (Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients), which is not on this map. Cited by 281 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
281citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06501118 narecruitingnot on this mapstarted 2024, after this paper: background citation

Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients

TypeinterventionalSponsorUniversity of Colorado, DenverRan2024 to 2026Enrolled3,600ConditionsRespiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, HypoxemiaArmsEducation, Epic notification alert
3 · Its place in the literature

Who cites it

281 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Guideline
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  3. Pooled it
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  9. Quality of life following adult veno-venous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Pooled it
  10. Natural History of Cognitive Impairment in Critical Illness Survivors. A Systematic Review.American journal of respiratory and critical care medicine · 2020
    Pooled it
  11. Guideline
  12. Pooled it
  13. Trial
  14. Trial
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  20. Patients' Adaptations After Acute Respiratory Distress Syndrome: A Qualitative Study.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2021
    Trial

221 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Mark E MikkelsenPulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, 836 W. Gates Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA. mark.mikkelsen@uphs.upenn.edu
Jason D Christie
Paul N Lanken
Rosette C Biester
B Taylor Thompson
Scarlett L Bellamy
A Russell Localio
Ejigayehu Demissie
Ramona O Hopkins
Derek C Angus

Funding

Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
CCTG FOR CLINICAL NETWORK FOR ARDS TREATMENTN01HR046058 · HR · UNIVERSITY OF PENNSYLVANIA · PI LANKEN, PAUL N · 1994 to 2000
$408k
CCTG NETWORK FOR ARDS TREATMENTN01HR016146 · HR · BAYLOR COLLEGE OF MEDICINE · PI GUNTUPALLI, KALPALATHA K · 2001 to 2001
$297k
NHLBI NIH HHS N01 HR016146NHLBI NIH HHS N01 HR046058NHLBI NIH HHS N01-HR-16146-54NHLBI NIH HHS N01-HR-46046-64NHLBI NIH HHS N01-HR-46058NHLBI NIH HHS T32 HL007891NHLBI NIH HHS T32 HL07891
6 · The paper itself

Abstract

rationaleCognitive and psychiatric morbidity is common and potentially modifiable after acute lung injury (ALI). However, practical measures of neuropsychological function for use in multicenter trials are lacking.

objectivesTo determine whether a validated telephone-based neuropsychological test battery is feasible in a multicenter trial. To determine the frequency and risk factors for long-term neuropsychological impairment.

methodsAs an adjunct study to the Acute Respiratory Distress Syndrome Clinical Trials Network Fluid and Catheter Treatment Trial, we assessed neuropsychological function at 2 and 12 months post-hospital discharge. MEASUREMENTS AND MAIN

resultsOf 406 eligible survivors, we approached 261 to participate and 213 consented. We tested 122 subjects at least once, including 102 subjects at 12 months. Memory, verbal fluency, and executive function were impaired in 13% (12 of 92), 16% (15 of 96), and 49% (37 of 76) of long-term survivors. Long-term cognitive impairment was present in 41 of the 75 (55%) survivors who completed cognitive testing. Depression, post-traumatic stress disorder, or anxiety was present in 36% (37 of 102), 39% (40 of 102), and 62% (63 of 102) of long-term survivors. Enrollment in a conservative fluid-management strategy (P = 0.005) was associated with cognitive impairment and lower partial pressure of arterial oxygen during the trial was associated with cognitive (P = 0.02) and psychiatric impairment (P = 0.02).

conclusionsNeuropsychological function can be assessed by telephone in a multicenter trial. Long-term neuropsychological impairment is common in survivors of ALI. Hypoxemia is a risk factor for long-term neuropsychological impairment. Fluid management strategy is a potential risk factor for long-term cognitive impairment; however, given the select population studied and an unclear mechanism, this finding requires confirmation.

Indexed as

Neuropsychological TestsAcute Lung InjuryAdultAnxiety DisordersCognition DisordersCritical IllnessDepressionFemaleFollow-Up StudiesHumansIncidenceLogistic ModelsMaleMiddle AgedMultivariate AnalysisProspective Studies

Identifiers

PMID22492988
PMCPMC3381234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.