Evidence map›Paper›PMID 22492947›Full record

ReviewCirculation2012

Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease.

Jason C Kovacic, Nadia Mercader, Miguel Torres, Manfred Boehm, Valentin Fuster

Abstract readReview
In one paragraph

Review in Circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 253 papers.

0numbers the graph read from it
0cells of the map it votes in
253citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

253 citing papers in PubMed.

  1. Trial
  2. Translational biology of human cardiac fibrosis.Nature cardiovascular research · 2026
    Review
  3. Review
  4. Review
  5. Differential transcriptomic and metabolomic landscape between human hearts donated after cardiac vs brain death.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. BMPR2 affects valve development via ECM-receptor interaction in zebrafish.Frontiers in cell and developmental biology · 2026
    Article
  14. Article
  15. Review
  16. Regulation of inflammatory lung injury and repair by transforming growth factors.American journal of physiology. Lung cellular and molecular physiology · 2025
    Review
  17. Article
  18. Review
  19. Article
  20. Article

193 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jason C KovacicZena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA. jason.kovacic@mountsinai.org
Nadia Mercader
Miguel Torres
Manfred Boehm
Valentin Fuster

Funding

Coronary Revascularization in Diabetic PatientsU01HL071988 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FUSTER, VALENTIN · 2004 to 2011
$24.2M
Vascular remodeling in patients with rare genetic disordersZIAHL006077 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BOEHM, MANFRED · 2010 to 2025
$22.9M
iPS-technology and patient specific disease modelsZIAHL006079 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BOEHM, MANFRED · 2010 to 2025
$14.4M
Murine models of vascular remodelingZIAHL006078 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BOEHM, MANFRED · 2010 to 2025
$11.4M
TRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007824 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GELB, BRUCE D · 1995 to 2022
$8.6M
Cellular and molecular mechanisms of endothelial repair and atherosclerosisK08HL111330 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVACIC, JASON CIRIL · 2012 to 2016
$647k
Intramural NIH HHS ZIA HL006078NHLBI NIH HHS 1K08HL111330-01NHLBI NIH HHS 5U01HL071988-07NHLBI NIH HHS K08 HL111330NHLBI NIH HHS T32 HL007824
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Epithelial-Mesenchymal TransitionAnimalsEndotheliumFibrosisHeartHeart ValvesHumansMyocardiumSignal TransductionT-Box Domain ProteinsTransforming Growth Factor betaT-Box Domain ProteinsTbx18 protein, humanTransforming Growth Factor beta

Identifiers

PMID22492947
PMCPMC3333843

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.