ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2012
The hibernating 13-lined ground squirrel as a model organism for potential cold storage of platelets.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death.bioRxiv : the preprint server for biology · 2024Article
- The mRNA NAnimals : an open access journal from MDPI · 2024Article
- Article
- Cold-induced FOXO1 nuclear transport aids cold survival and tissue storage.Nature communications · 2024Article
- Blood transcriptomics mirror regulatory mechanisms during hibernation-a comparative analysis of the Djungarian hamster with other mammalian species.Pflugers Archiv : European journal of physiology · 2023Article
- Hibernation and hemostasis.Frontiers in physiology · 2023Review
- Platelets from 13-lined ground squirrels are resistant to cold storage lesions.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Platelet proteome dynamics in hibernating 13-lined ground squirrels.Physiological genomics · 2021Article
- Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol.Communications biology · 2021Article
- Reversible thrombocytopenia during hibernation originates from storage and release of platelets in liver sinusoids.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- The spleen morphophysiology of fruit bats.Anatomia, histologia, embryologia · 2019Article
- Cardiovascular resistance to thrombosis in 13-lined ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- Article
- A dramatic blood plasticity in hibernating and 14-day hindlimb unloading Daurian ground squirrels (Spermophilus dauricus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Temperature effects on the activity, shape, and storage of platelets from 13-lined ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Effects of hibernation on bone marrow transcriptome in thirteen-lined ground squirrels.Physiological genomics · 2016Article
- Von Willebrand factor is reversibly decreased during torpor in 13-lined ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Hypothermia: effects on platelet function and hemostasis.Thrombosis journal · 2014Article
- Platelet dynamics during natural and pharmacologically induced torpor and forced hypothermia.PloS one · 2014Article
- How hibernation and hypothermia help to improve anticoagulant control.Temperature (Austin, Tex.)Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Hibernating mammals have developed many physiological adaptations to extreme environments. During hibernation, 13-lined ground squirrels (Ictidomys tridecemlineatus) must suppress hemostasis to survive prolonged body temperatures of 4-8°C and 3-5 heartbeats per minute without forming lethal clots. Upon arousal in the spring, these ground squirrels must be able to quickly restore normal clotting activity to avoid bleeding. Here we show that ground squirrel platelets stored in vivo at 4-8°C were released back into the blood within 2 h of arousal in the spring with a body temperature of 37°C but were not rapidly cleared from circulation. These released platelets were capable of forming stable clots and remained in circulation for at least 2 days before newly synthesized platelets were detected. Transfusion of autologous platelets stored at 4°C or 37°C showed the same clearance rates in ground squirrels, whereas rat platelets stored in the cold had a 140-fold increase in clearance rate. Our results demonstrate that ground squirrel platelets appear to be resistant to the platelet cold storage lesions observed in other mammals, allowing prolonged storage in cold stasis and preventing rapid clearance upon spring arousal. Elucidating these adaptations could lead to the development of methods to store human platelets in the cold, extending their shelf life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.