ArticleThe Plant cell2012
Requirement of the cytosolic interaction between PATHOGENESIS-RELATED PROTEIN10 and LEUCINE-RICH REPEAT PROTEIN1 for cell death and defense signaling in pepper.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.
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Who cites it
110 citing papers in PubMed, 1 synthesis or guideline pooled it, 217 citations in OpenAlex.
- Pathogenesis-related protein 10 in resistance to biotic stress: progress in elucidating functions, regulation and modes of action.Frontiers in plant science · 2023Pooled it
- Genome-wide analysis of WRKY gene family in Cucurbita moschata and involvement of CmWRKY22/63/84 in powdery mildew resistance.BMC genomics · 2026Article
- Selected cell wall-associated components in plant defense responses against microbial pathogens.Frontiers in plant science · 2026Review
- FaMYB63 and FvWYRKY75 Activate FvPR10.14 Boosting Strawberry Immunity Against Powdery Mildew.Molecular plant pathology · 2025Article
- Article
- RNA-binding proteins orchestrating immunity in plants.The Plant journal : for cell and molecular biology · 2025Review
- A mini-review on the role of leucine-rich repeat receptor-like kinases (LRR-RLKs) in plant responses to drought stress.Molecular biology reports · 2025Review
- Association of the tomato co-chaperone geneHorticulture research · 2025Article
- Heterologous expression of Halostachys caspica pathogenesis-related protein 10 increases salt and drought resistance in transgenic Arabidopsis thaliana.Plant molecular biology · 2024Article
- Genome-Wide Identification of PR10 Family Members in Durum Wheat: Expression Profile and In Vitro Analyses of TdPR10.1 in Response to Various Stress Conditions.Plants (Basel, Switzerland) · 2024Article
- CaARP1/CaSGT1 Module Regulates Vegetative Growth and Defense Response of Pepper Plants againstPlants (Basel, Switzerland) · 2024Article
- Integrated Biological Experiments and Proteomic Analyses ofInternational journal of molecular sciences · 2024Article
- Sugarcane ScOPR1 gene enhances plant disease resistance through the modulation of hormonal signaling pathways.Plant cell reports · 2024Article
- Genome-wide identification of rubber tree pathogenesis-related 10 (PR-10) proteins with biological relevance to plant defense.Scientific reports · 2024Article
- A LlWRKY33-LlHSFA4-LlCAT2 module confers resistance toHorticulture research · 2024Article
- Integrated proteomic analysis reveals interactions between phosphorylation and ubiquitination in rose response toHorticulture research · 2024Article
- Dual functionality of pathogenesis-related proteins: defensive role in plants versus immunosuppressive role in pathogens.Frontiers in plant science · 2024Article
- Pathogenesis-Related Proteins (PRs) with Enzyme Activity Activating Plant Defense Responses.Plants (Basel, Switzerland) · 2023Review
- CaREM1.4 interacts with CaRIN4 to regulateHorticulture research · 2023Article
- Salicylic acid-related ribosomal protein CaSLP improves drought and Pst.DC3000 tolerance in pepper.Molecular horticulture · 2023Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants recruit innate immune receptors such as leucine-rich repeat (LRR) proteins to recognize pathogen attack and activate defense genes. Here, we identified the pepper (Capsicum annuum) pathogenesis-related protein10 (PR10) as a leucine-rich repeat protein1 (LRR1)-interacting partner. Bimolecular fluorescence complementation and coimmunoprecipitation assays confirmed the specific interaction between LRR1 and PR10 in planta. Avirulent Xanthomonas campestris pv vesicatoria infection induces PR10 expression associated with the hypersensitive cell death response. Transient expression of PR10 triggers hypersensitive cell death in pepper and Nicotiana benthamiana leaves, which is amplified by LRR1 coexpression as a positive regulator. LRR1 promotes the ribonuclease activity and phosphorylation of PR10, leading to enhanced cell death signaling. The LRR1-PR10 complex is formed in the cytoplasm, resulting in its secretion into the apoplastic space. Engineered nuclear confinement of both proteins revealed that the cytoplasmic localization of the PR10-LRR1 complex is essential for cell death-mediated defense signaling. PR10/LRR1 silencing in pepper compromises resistance to avirulent X. campestris pv vesicatoria infection. By contrast, PR10/LRR1 overexpression in Arabidopsis thaliana confers enhanced resistance to Pseudomonas syringae pv tomato and Hyaloperonospora arabidopsidis. Together, these results suggest that the cytosolic LRR-PR10 complex is responsible for cell death-mediated defense signaling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.