ArticleJournal of immunology (Baltimore, Md. : 1950)2012
T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Selective capacity of metreleptin administration to reconstitute CD4+ T-cell number in females with acquired hypoleptinemia.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity.Cancer cell · 2025Article
- E-cadherin maintains the undifferentiated state of mouse spermatogonial progenitor cells via β-catenin.Cell & bioscience · 2022Article
- Downregulation of TCF1 in HIV Infection Impairs T-cell Proliferative Capacity by Disrupting Mitochondrial Function.Frontiers in microbiology · 2022Article
- TCF-1 regulates HIV-specific CD8+ T cell expansion capacity.JCI insight · 2021Article
- A key control point in the T cell response to chronic infection and neoplasia: FOXO1.Current opinion in immunology · 2020Review
- Effects of Glycogen Synthase Kinase-3β Inhibitor TWS119 on Proliferation and Cytokine Production of TILs From Human Lung Cancer.Journal of immunotherapy (Hagerstown, Md. : 1997) · 2018Article
- Transcriptional and epigenetic regulation of innate-like T lymphocyte development.Current opinion in immunology · 2018Review
- Temporal regulation of Wnt/β-catenin signaling is important for invariant NKT cell development and terminal maturation.Molecular immunology · 2017Article
- IL-4 and IL-15 promotion of virtual memory CD8European journal of immunology · 2016Article
- Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis.JCI insight · 2016Article
- NFAT2 Regulates Generation of Innate-Like CD8Frontiers in immunology · 2016Article
- β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation.BMC immunology · 2015Article
- The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation.The Journal of experimental medicine · 2015Article
- Innate memory T cells.Advances in immunology · 2015Review
- A critical role for the regulated wnt-myc pathway in naive T cell survival.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- ID'ing innate and innate-like lymphoid cells.Immunological reviews · 2014Review
- From inception to output, Tcf1 and Lef1 safeguard development of T cells and innate immune cells.Immunologic research · 2014Review
- Dendritic cell-MHC class II and Itk regulate functional development of regulatory innate memory CD4+ T cells in bone marrow transplantation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Innate memory-like CD8 thymocytes develop and acquire effector function during maturation in the absence of encounter with Ags. In this study, we demonstrate that enhanced function of transcription factors T cell factor (TCF)-1 and β-catenin regulate the frequency of promyelocytic leukemia zinc finger (PLZF)-expressing, IL-4-producing thymocytes that promote the generation of eomesodermin-expressing memory-like CD8 thymocytes in trans. In contrast, TCF1-deficient mice do not have PLZF-expressing thymocytes and eomesodermin-expressing memory-like CD8 thymocytes. Generation of TCF1 and β-catenin-dependent memory-like CD8 thymocytes is non-cell-intrinsic and requires the expression of IL-4 and IL-4R. CD8 memory-like thymocytes migrate to the peripheral lymphoid organs, and the memory-like CD8 T cells rapidly produce IFN-γ. Thus, TCF1 and β-catenin regulate the generation of PLZF-expressing thymocytes and thereby facilitate the generation of memory-like CD8 T cells in the thymus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.