Trial reportStroke2012
Baseline cardiovascular risk predicts subsequent changes in resting brain function.
Trial report in Stroke, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Interpreting fMRI Studies in Populations with Cerebrovascular Risk: The Use of a Subject-Specific Hemodynamic Response Function.Behavioral sciences (Basel, Switzerland) · 2025Article
- Volumetric brain MRI signatures of heart failure with preserved ejection fraction in the setting of dementia.Magnetic resonance imaging · 2024Article
- Sleep quality associate with the increased prevalence of cognitive impairment in coronary artery disease patients: A retrospective case-control study.Open medicine (Warsaw, Poland) · 2024Article
- The Benefits of Physical Activity in Individuals with Cardiovascular Risk Factors: A Longitudinal Investigation Using fNIRS and Dual-Task Walking.Journal of clinical medicine · 2021Article
- Frontostriatal Brain Activation Is Associated With the Longitudinal Progression of Cardiometabolic Risk.Psychosomatic medicine · 2020Article
- Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans.Journal of Alzheimer's disease : JAD · 2020Article
- Path Integration Changes as a Cognitive Marker for Vascular Cognitive Impairment?-A Pilot Study.Frontiers in human neuroscience · 2020Article
- Cardiovascular risk and encoding-related hippocampal connectivity in older adults.BMC neuroscience · 2019Article
- Improved perfusion pattern score association with type 2 diabetes severity using machine learning pipeline: Pilot study.Journal of magnetic resonance imaging : JMRI · 2019Article
- Thalamic functional connectivity and its association with behavioral performance in older age.Brain and behavior · 2018Article
- Impact of Metabolic Diseases on Cerebral Circulation: Structural and Functional Consequences.Comprehensive Physiology · 2018Review
- Diabetic Microvascular Disease: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2017Review
- Compensatory functional reorganization may precede hypertension-related brain damage and cognitive decline: a functional magnetic resonance imaging study.Journal of hypertension · 2017Article
- Prehypertensive Blood Pressures and Regional Cerebral Blood Flow Independently Relate to Cognitive Performance in Midlife.Journal of the American Heart Association · 2017Article
- Dynamic association between perfusion and white matter integrity across time since injury in Veterans with history of TBI.NeuroImage. Clinical · 2017Article
- Cerebrovascular complications of diabetes: focus on cognitive dysfunction.Clinical science (London, England : 1979) · 2016Review
- Vascular risk factors, cerebrovascular reactivity, and the default-mode brain network.NeuroImage · 2015Article
- The Effects of Aerobic Exercise on Cognitive and Neural Decline in Aging and Cardiovascular Disease.Current geriatrics reports · 2014Article
- Cardiovascular risks and brain function: a functional magnetic resonance imaging study of executive function in older adults.Neurobiology of aging · 2014Article
- Type 2 diabetes and cognitive impairment: contributions from neuroimaging.Journal of geriatric psychiatry and neurology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
background and purposeThe Framingham Heart Study group cardiovascular disease risk profile (FCRP) score was used to assess the relationship between baseline cardiovascular risk and subsequent changes in resting state cerebral blood flow (CBF) in cognitively normal older participants from the Baltimore Longitudinal Study of Aging.
methodsNinty-seven cognitively normal participants underwent annual resting-state positron emission tomography scans at baseline and over a period of up to 8 years (mean interval, 7.4 years). Images quantifying voxel-wise longitudinal rates of CBF change were calculated and used to examine the relationship between baseline FCRP score and changes over time in regional CBF. Individual components of the FCRP score (age, cholesterol, blood pressure, smoking status, and type 2 diabetes) were also correlated with changes in regional CBF to examine the independent contributions of each component to the overall pattern of change.
resultsHigher baseline FCRP scores were associated with accelerated longitudinal decline in CBF in orbitofrontal, medial frontal/anterior cingulate, insular, precuneus, and brain stem regions. Of the components that comprise the FCRP score, higher diastolic blood pressure and diabetes were associated independently with greater decline in the medial frontal/anterior cingulate and insular regions, respectively.
conclusionsBaseline cardiovascular risk factors are associated with greater rates of decline in resting state regional brain function. The regions showing accelerated decline participate in higher-order cognitive processes and are also vulnerable to age-related neuropathology. These results, in conjunction with other studies, encourage early treatment of cardiovascular risk factors in older individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.