ArticleCirculation. Cardiovascular imaging2012
Regional coronary endothelial function is closely related to local early coronary atherosclerosis in patients with mild coronary artery disease: pilot study.
Article in Circulation. Cardiovascular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Inflammation and Coronary Endothelial Function in Patients With Coronary Artery Disease
Inflammatory Pathogenesis of Coronary Atherosclerosis in HIV
Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- Feasibility of coronary endothelial function assessment using arterial spin labeled CMR.NMR in biomedicine · 2020Trial
- Trial
- Association between left ventricular remodeling and coronary chronic total occlusion in hypertensive coronary artery disease patients.Scientific reports · 2025Article
- Coronary artery endothelial function and aging in people with HIV and HIV-negative individuals.American journal of physiology. Heart and circulatory physiology · 2023Article
- Effect of Sex on Coronary Endothelial Dysfunction in People Living With HIV.Journal of the American Heart Association · 2022Article
- Pathophysiology of Atherosclerosis.International journal of molecular sciences · 2022Review
- Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health.Frontiers in cardiovascular medicine · 2022Review
- Volumetric coronary endothelial function assessment: a feasibility study exploiting stack-of-stars 3D cine MRI and image-based respiratory self-gating.NMR in biomedicine · 2021Article
- Progression of Plaque Burden of Intracranial Atherosclerotic Plaque Predicts Recurrent Stroke/Transient Ischemic Attack: A Pilot Follow-Up Study Using Higher-Resolution MRI.Journal of magnetic resonance imaging : JMRI · 2021Article
- Randomized Trial of Anti-inflammatory Medications and Coronary Endothelial Dysfunction in Patients With Stable Coronary Disease.Frontiers in cardiovascular medicine · 2021Article
- The Cardiovascular Stress Response as Early Life Marker of Cardiovascular Health: Applications in Population-Based Pediatric Studies-A Narrative Review.Pediatric cardiology · 2020Review
- In vitro optimization and comparison of CT angiography versus radial cardiovascular magnetic resonance for the quantification of cross-sectional areas and coronary endothelial function.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Article
- Precision and accuracy of cross-sectional area measurements used to measure coronary endothelial function with spiral MRI.Magnetic resonance in medicine · 2019Article
- Regional coronary endothelial dysfunction is related to the degree of local epicardial fat in people with HIV.Atherosclerosis · 2018Article
- Coronary Endothelial Dysfunction Is Associated With Elevated Serum PCSK9 Levels in People With HIV Independent of Low-Density Lipoprotein Cholesterol.Journal of the American Heart Association · 2018Article
- Self-gated golden angle spiral cine MRI for coronary endothelial function assessment.Magnetic resonance in medicine · 2018Article
- Responses of Endothelial Cells Towards Ischemic Conditioning Following Acute Myocardial Infarction.Conditioning medicine · 2018Article
- Study of correlation between wall shear stress and elasticity in atherosclerotic carotid arteries.Biomedical engineering online · 2018Article
- Correlation between quantitative analysis of wall shear stress and intima-media thickness in atherosclerosis development in carotid arteries.Biomedical engineering online · 2017Article
- Local coronary wall eccentricity and endothelial function are closely related in patients with atherosclerotic coronary artery disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundCoronary endothelial function is abnormal in patients with established coronary artery disease and was recently shown by MRI to relate to the severity of luminal stenosis. Recent advances in MRI now allow the noninvasive assessment of both anatomic and functional (endothelial function) changes that previously required invasive studies. We tested the hypothesis that abnormal coronary endothelial function is related to measures of early atherosclerosis such as increased coronary wall thickness. METHODS AND
resultsSeventeen arteries in 14 healthy adults and 17 arteries in 14 patients with nonobstructive coronary artery disease were studied. To measure endothelial function, coronary MRI was performed before and during isometric handgrip exercise, an endothelial-dependent stressor, and changes in coronary cross-sectional area and flow were measured. Black blood imaging was performed to quantify coronary wall thickness and indices of arterial remodeling. The mean stress-induced change in cross-sectional area was significantly higher in healthy adults (13.5%±12.8%, mean±SD, n=17) than in those with mildly diseased arteries (-2.2%±6.8%, P<0.0001, n=17). Mean coronary wall thickness was lower in healthy subjects (0.9±0.2 mm) than in patients with coronary artery disease (1.4±0.3 mm, P<0.0001). In contrast to healthy subjects, stress-induced changes in cross-sectional area, a measure of coronary endothelial function, correlated inversely with coronary wall thickness in patients with coronary artery disease (r=-0.73, P=0.0008).
conclusionsThere is an inverse relationship between coronary endothelial function and local coronary wall thickness in patients with coronary artery disease but not in healthy adults. These findings demonstrate that local endothelial-dependent functional changes are related to the extent of early anatomic atherosclerosis in mildly diseased arteries. This combined MRI approach enables the anatomic and functional investigation of early coronary disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.