ReviewGlycobiology2012
Infection, inflammation and host carbohydrates: a Glyco-Evasion Hypothesis.
Review in Glycobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 87 citations in OpenAlex.
- Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines.Applied microbiology and biotechnology · 2023Article
- α2,6-Sialylation is Upregulated in Severe COVID-19 Implicating the Complement Cascade.medRxiv : the preprint server for health sciences · 2022Article
- Advances in glycoscience to understand viral infection and colonization.Nature methods · 2022Article
- Article
- Article
- Mucin signature as a potential tool to predict susceptibility to COVID-19.Physiological reports · 2021Review
- Adhesion ofFrontiers in molecular biosciences · 2021Review
- Glycomic analysis of host response reveals high mannose as a key mediator of influenza severity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties.Materials today. Bio · 2020Article
- Immune-mediated thrombotic thrombocytopenic purpura in patients with and without systemic lupus erythematosus: a retrospective study.Orphanet journal of rare diseases · 2020Article
- Glycoproteome in silkworm Bombyx mori and alteration by BmCPV infection.Journal of proteomics · 2020Article
- Disruption of hepatocyte Sialylation drives a T cell-dependent pro-inflammatory immune tone.Glycoconjugate journal · 2020Article
- Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation.Mucosal immunology · 2020Article
- A Higher Abundance of O-Linked Glycans Confers a Selective Advantage to High Fertile Buffalo Spermatozoa for Immune-Evasion From Neutrophils.Frontiers in immunology · 2020Article
- Effects of central and peripheral administration of an acute-phase protein, α-1-acid-glycoprotein, on feed intake and rectal temperature in sheep.Journal of animal science · 2019Article
- Article
- Wound healing in post-smolt Atlantic salmon (Salmo salar L.).Scientific reports · 2019Article
- Plasma glycomics predict cardiovascular disease in patients with ART-controlled HIV infections.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Precursor ion survival energies of protonated N-glycopeptides and their weak dependencies on high mannose N-glycan composition in collision-induced dissociation.The Analyst · 2018Article
- Position of human blood group O(H) and phenotype-determining enzymes in growth and infectious disease.Annals of the New York Academy of Sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Microbial immune evasion can be achieved through the expression, or mimicry, of host-like carbohydrates on the microbial cell surface to hide from detection. However, disparate reports collectively suggest that evasion could also be accomplished through the modulation of the host glycosylation pathways, a mechanism that we call the "Glyco-Evasion Hypothesis". Here, we will summarize the evidence in support of this paradigm by reviewing three separate bodies of work present in the literature. We review how infection and inflammation can lead to host glycosylation changes, how host glycosylation changes can increase susceptibility to infection and inflammation and how glycosylation impacts molecular and cellular function. Then, using these data as a foundation, we propose a unifying hypothesis in which microbial products can hijack host glycosylation to manipulate the immune response to the advantage of the pathogen. This model reveals areas of research that we believe could significantly improve our fight against infectious disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.