ArticleThe American journal of tropical medicine and hygiene2012
Association of in utero sensitization to Schistosoma haematobium with enhanced cord blood IgE and increased frequencies of CD5- B cells in African newborns.
Article in The American journal of tropical medicine and hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Placental gene expression and antibody levels of mother-neonate pairs reveal an enhanced risk for inflammation in a helminth endemic country.Scientific reports · 2019Trial
- The effect of maternal helminth infection on maternal and neonatal immune function and immunity to tuberculosis.PloS one · 2014Trial
- Maternal IgE Influence on Fetal and Infant Health.Immunological reviews · 2025Review
- Reduced plasma levels of GM-CSF is a common feature ofFrontiers in immunology · 2025Article
- Altered Offspring Immunity in Maternal Parasitic Infections.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- HIV, Cytomegalovirus, and Malaria Infections during Pregnancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan Neonates.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Maternal Schistosomiasis: Immunomodulatory Effects With Lasting Impact on Allergy and Vaccine Responses.Frontiers in immunology · 2018Review
- Impact of parental obesity on neonatal markers of inflammation and immune response.International journal of obesity (2005) · 2017Article
- Getting the basic rights - the role of water, sanitation and hygiene in maternal and reproductive health: a conceptual framework.Tropical medicine & international health : TM & IH · 2015Article
- Immunology of human schistosomiasis.Parasite immunology · 2014Review
- Detection of immunoglobulin isotypes from dried blood spots.Journal of immunological methods · 2014Article
- Maternal infection with Schistosoma japonicum induces a profibrotic response in neonates.Infection and immunity · 2014Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated in utero priming as a consequence of maternal parasitic infections. Cord blood plasma samples of 63 African newborns were assessed by enzyme-linked immunosorbent assay for their content of total and schistosome-specific or filaria-specific IgE and IgG4. The frequencies of lymphocyte phenotypes in cord blood were also determined by using flow cytometry, and were compared with those of European newborns. We found significantly increased schistosome soluble egg antigen (SEA)-specific IgE in cord plasma of those born to mothers with schistosome infections and correlations between fetal and maternal SEA-specific and filaria antigen-specific IgE. These data are evidence for in utero priming of the fetal immune system to maternal helminth infections. Furthermore, we show significantly enhanced percentages of CD5- B cells in African newborns cord blood compared with Europeans, which is consistent with earlier maturation of the African fetal immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.