ArticleProceedings. Biological sciences2012
Host modulation of parasite competition in multiple infections.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Effects of gastrointestinal parasites on fecal glucocorticoids and behaviour in vervet monkeys (Chlorocebus pygerythrus).PloS one · 2025Article
- Molecular Identification of Selected Cervid Helminths in Supplementarily Fed European Bison Population.Journal of parasitology research · 2024Article
- Immune-mediated competition benefits protective microbes over pathogens in a novel host species.Heredity · 2022Article
- Empirical Support for the Pattern of Competitive Exclusion between Insect Parasitic Fungi.Journal of fungi (Basel, Switzerland) · 2021Article
- Sex-biased polyparasitism in moose (International journal for parasitology. Parasites and wildlife · 2020Article
- Host specificity and microhabitat preference of symbiotic copepods (Cyclopoida: Clausiididae) associated with ghost shrimps (Decapoda: Callichiridae, Callianideidae).Ecology and evolution · 2020Article
- Prevalence, seasonal and geographical distribution of parasitic diseases in dogs in Plateau State Nigeria: a 30-year retrospective study (1986-2015).Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Parasite species co-occurrence patterns onInternational journal for parasitology. Parasites and wildlife · 2020Article
- Characterising interactions between co-infecting parasites using age-intensity profiles.International journal for parasitology · 2020Article
- Detecting parasite associations within multi-species host and parasite communities.Proceedings. Biological sciences · 2019Article
- Genomic Variation among Strains ofmSphere · 2019Article
- Infection against infection: parasite antagonism against parasites, viruses and bacteria.Infectious diseases of poverty · 2019Review
- Twice upon a time: The progression of canine visceral leishmaniasis in an Argentinean city.PloS one · 2019Article
- Diversity analysis of MSP1 identifies conserved epitope organization in block 2 amidst high sequence variability in Indian Plasmodium falciparum isolates.Malaria journal · 2018Article
- Contrasting indirect effects of an ant host on prey-predator interactions of symbiotic arthropods.Oecologia · 2018Article
- Population screening and transmission experiments indicate paramyxid-microsporidian co-infection in Echinogammarus marinus represents a non-hyperparasitic relationship between specific parasite strains.Scientific reports · 2018Article
- Ants avoid superinfections by performing risk-adjusted sanitary care.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- orco Mutagenesis Causes Loss of Antennal Lobe Glomeruli and Impaired Social Behavior in Ants.Cell · 2017Article
- Community structure of helminth parasites in two closely related South African rodents differing in sociality and spatial behaviour.Parasitology research · 2017Article
- Temporal and demographic blood parasite dynamics in two free-ranging neotropical primates.International journal for parasitology. Parasites and wildlife · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parasite diversity is a constant challenge to host immune systems and has important clinical implications, but factors underpinning its emergence and maintenance are still poorly understood. Hosts typically harbour multiple parasite genotypes that share both host resources and immune responses. Parasite diversity is thus shaped not only by resource competition between co-infecting parasites but also by host-driven immune-mediated competition. We investigated these effects in an insect-trypanosome system, combining in vivo and in vitro single and double inoculations. In vivo, a non-pathogenic, general immune challenge was used to manipulate host immune condition and resulted in a reduced ability of hosts to defend against a subsequent exposure to the trypanosome parasites, illustrating the costs of immune activation. The associated increase in available host space benefited the weaker parasite strains of each pair as much as the otherwise more competitive strains, resulting in more frequent multiple infections in immune-challenged hosts. In vitro assays showed that in the absence of a host, overall parasite diversity was minimal because the outcome of competition was virtually fixed and resulted in strain extinction. Altogether, this shows that parasite competition is largely host-mediated and suggests a role for host immune condition in the maintenance of parasite diversity.
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