ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
The RNA-binding protein human antigen R controls global changes in gene expression during Schwann cell development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination.Science advances · 2024Article
- Increased ANKRD1 Levels in Early Senescence Mediated by RBMS1-ElicitedMolecular and cellular biology · 2024Article
- HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis.The Journal of clinical investigation · 2020Article
- Human antigen R-regulated mRNA metabolism promotes the cell motility of migrating mouse neurons.Development (Cambridge, England) · 2020Article
- Soluble Neuregulin1 Down-Regulates Myelination Genes in Schwann Cells.Frontiers in molecular neuroscience · 2018Article
- DO-RIP-seq to quantify RNA binding sites transcriptome-wide.Methods (San Diego, Calif.) · 2017Article
- Quantifying RNA binding sites transcriptome-wide using DO-RIP-seq.RNA (New York, N.Y.) · 2017Article
- Article
- RNA-binding protein Rbm47 binds to Nanog in mouse embryonic stem cells.Molecular biology reports · 2013Article
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Authors and funding
16 authors at 7 institutions in 4 countries.
Funding
Abstract
An important prerequisite to myelination in peripheral nerves is the establishment of one-to-one relationships between axons and Schwann cells. This patterning event depends on immature Schwann cell proliferation, apoptosis, and morphogenesis, which are governed by coordinated changes in gene expression. Here, we found that the RNA-binding protein human antigen R (HuR) was highly expressed in immature Schwann cells, where genome-wide identification of its target mRNAs in vivo in mouse sciatic nerves using ribonomics showed an enrichment of functionally related genes regulating these processes. HuR coordinately regulated expression of several genes to promote proliferation, apoptosis, and morphogenesis in rat Schwann cells, in response to NRG1, TGFβ, and laminins, three major signals implicated in this patterning event. Strikingly, HuR also binds to several mRNAs encoding myelination-related proteins but, contrary to its typical function, negatively regulated their expression, likely to prevent ectopic myelination during development. These functions of HuR correlated with its abundance and subcellular localization, which were regulated by different signals in Schwann cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.