ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Deterministic and stochastic neuronal contributions to distinct synchronous CA3 network bursts.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
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- Massively augmented hippocampal dentate granule cell activation accompanies epilepsy development.Scientific reports · 2017Article
- Modulation of Neural Network Activity through Single Cell Ablation: An in Vitro Model of Minimally Invasive Neurosurgery.Molecules (Basel, Switzerland) · 2016Article
- Inferring Neuronal Dynamics from Calcium Imaging Data Using Biophysical Models and Bayesian Inference.PLoS computational biology · 2016Article
- Gradient Index Microlens Implanted in Prefrontal Cortex of Mouse Does Not Affect Behavioral Test Performance over Time.PloS one · 2016Article
- NeuroCa: integrated framework for systematic analysis of spatiotemporal neuronal activity patterns from large-scale optical recording data.Neurophotonics · 2015Article
- Preictal activity of subicular, CA1, and dentate gyrus principal neurons in the dorsal hippocampus before spontaneous seizures in a rat model of temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging.Nature communications · 2014Article
- Recording from over 1,000 cells: a new toy in place for epilepsy research?Epilepsy currents · 2014Article
- Extracellular calcium controls the expression of two different forms of ripple-like hippocampal oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Network models predict that reduced excitatory fluctuations can give rise to hippocampal network hyper-excitability in MeCP2-null mice.PloS one · 2014Article
- Spatially clustered neuronal assemblies comprise the microstructure of synchrony in chronically epileptic networks.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Protracted postnatal development of sparse, specific dentate granule cell activation in the mouse hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Synconset waves and chains: spiking onsets in synchronous populations predict and are predicted by network structure.PloS one · 2013Article
- In vitro large-scale experimental and theoretical studies for the realization of bi-directional brain-prostheses.Frontiers in neural circuits · 2013Article
- Dyeing to be fired: firing order distinguishes two types of bursting activity.Epilepsy currents · 2012Article
- Model-free reconstruction of excitatory neuronal connectivity from calcium imaging signals.PLoS computational biology · 2012Article
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6 authors.
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Abstract
Computational studies have suggested that stochastic, deterministic, and mixed processes all could be possible determinants of spontaneous, synchronous network bursts. In the present study, using multicellular calcium imaging coupled with fast confocal microscopy, we describe neuronal behavior underlying spontaneous network bursts in developing rat and mouse hippocampal area CA3 networks. Two primary burst types were studied: giant depolarizing potentials (GDPs) and spontaneous interictal bursts recorded in bicuculline, a GABA(A) receptor antagonist. Analysis of the simultaneous behavior of multiple CA3 neurons during synchronous GDPs revealed a repeatable activation order from burst to burst. This was validated using several statistical methods, including high Kendall's coefficient of concordance values for firing order during GDPs, high Pearson's correlations of cellular activation times between burst pairs, and latent class analysis, which revealed a population of 5-6% of CA3 neurons reliably firing very early during GDPs. In contrast, neuronal firing order during interictal bursts appeared homogeneous, with no particular cells repeatedly leading or lagging during these synchronous events. We conclude that GDPs activate via a deterministic mechanism, with distinct, repeatable roles for subsets of neurons during burst generation, while interictal bursts appear to be stochastic events with cells assuming interchangeable roles in the generation of these events.
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