Evidence map›Paper›PMID 22492023›Full record

ArticleIrish journal of medical science2013

A series of patients on anti-TNF therapy referred to a multidisciplinary lung cancer service.

C O'Connell, M Hensey, A B Mongey, D J Veale, S C Donnelly

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In one paragraph

Article in Irish journal of medical science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

C O'ConnellDepartment of Respiratory Medicine, Education & Research Centre, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
M Hensey
A B Mongey
D J Veale
S C Donnelly
St. Vincent's University Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiological therapies have significantly improved the quality of life of patients with aggressive collagen vascular diseases. Blocking TNF activity may potentially confer a higher malignant potential for patients.

aimsTo identify patients to whom anti-TNF therapies were recently prescribed and were referred to a multidisciplinary lung cancer service.

methodsRetrospective review of patients over an 18-month period who were referred to a multidisciplinary lung cancer service.

resultsThree patients who underwent recent anti-TNF therapies and presented with solid organ tumours. All had significant additional risks for cancer including smoking and family history and active connective tissue diseases with a past history of immunosuppressive therapies.

conclusionsOur series highlights the potential malignant risk of anti-TNF theraphy to a general medical audience.

Indexed as

AdalimumabAgedAntibodies, Monoclonal, HumanizedAntibodies, Monoclonal, Murine-DerivedAntirheumatic AgentsArthritis, RheumatoidCarcinoma, Squamous CellFatal OutcomeFemaleGranulomatosis with PolyangiitisHumansLung NeoplasmsMethotrexateMiddle AgedReferral and ConsultationRetrospective StudiesAdalimumabAntibodies, Monoclonal, HumanizedAntibodies, Monoclonal, Murine-DerivedAntirheumatic AgentsMethotrexateRituximabTumor Necrosis Factor-alpha

Identifiers

PMID22492023
OpenAlexW2007178810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.