ArticleCellular and molecular neurobiology2012
Investigating tonic Wnt signaling throughout the adult CNS and in the hippocampal neurogenic niche of BatGal and ins-TopGal mice.
Article in Cellular and molecular neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Analysis of β-Catenin Signalling Activity Suggests Differential Regulation of Ontogenetically Distinct Dentate Granule Neuron Populations.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Article
- Wnt/β-catenin signalling is dispensable for adult neural stem cell homeostasis and activation.Development (Cambridge, England) · 2021Article
- T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development.Frontiers in cell and developmental biology · 2021Review
- β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons.The EMBO journal · 2020Article
- Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease.Frontiers in cell and developmental biology · 2020Review
- Wnt/β-catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind.FEBS letters · 2019Review
- Frizzled-1 receptor regulates adult hippocampal neurogenesis.Molecular brain · 2016Article
- The Role of Wnt/β-Catenin Signaling Pathway in Disrupted Hippocampal Neurogenesis of Temporal Lobe Epilepsy: A Potential Therapeutic Target?Neurochemical research · 2015Review
- The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Wnts are expressed in the spinal cord of adult mice and are differentially induced after injury.Journal of neurotrauma · 2014Article
- Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt/β-catenin signaling.Stem cell reports · 2014Article
- Physiological role of β-catenin/TCF signaling in neurons of the adult brain.Neurochemical research · 2013Review
- Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.ACS chemical neuroscience · 2012Article
- Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression.Developmental neuroscience · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wnt/β-catenin signaling has a well-established role in the development of the central nervous system (CNS), and recent evidence is extending this role to include the regulation of adult hippocampal function, including neurogenesis within the dentate gyrus. While the neuroanatomical expression pattern of many canonical Wnt signaling components have been investigated, the sites of signal integration and functional downstream β-catenin activation remain comparatively less characterized in the adult CNS. Using two independent transgenic β-catenin-activated LacZ reporter mouse lines (BatGal and ins-TopGal), we demonstrate that Wnt/β-catenin signaling is active in discrete regions of the adult mouse CNS. Intriguingly, BatGal mice exhibit a broad pattern of reporter expression in the CNS, while expression in ins-TopGal mice is more restricted. Further investigation of these two lines reveals temporal differences in β-catenin-activated reporter expression during neurogenesis within the adult hippocampus. Ins-TopGal mice display peaks of Wnt/β-catenin-activated reporter expression during early and later stages of neurogenesis suggesting Wnt/β-catenin signaling plays an important role during both progenitor cell amplification as well as neuronal maturation, integration, and/or maintenance; however, results from BatGal mice are not as convincing. Thus our data using ins-TopGal mice are consistent with the idea that Wnt signaling plays diverse roles during adult hippocampal neurogenesis and support the idea that multiple transgenic reporter lines must be rigorously compared during scientific investigations.
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