ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2013
Denicotinized versus average nicotine tobacco cigarette smoking differentially releases striatal dopamine.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies.Psychopharmacology · 2019Pooled it
- Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Trial
- Differential dopamine release by psychosis-generating and non-psychosis-generating addictive substances in the nucleus accumbens and dorsomedial striatum.Translational psychiatry · 2021Article
- Brain substrates of early (4h) cigarette abstinence: Identification of treatment targets.Drug and alcohol dependence · 2018Article
- Investigating the neural correlates of smoking: Feasibility and results of combining electronic cigarettes with fMRI.Scientific reports · 2017Article
- A review of positron emission tomography studies exploring the dopaminergic system in substance use with a focus on tobacco as a co-variate.The American journal of drug and alcohol abuse · 2017Review
- Nicotine-specific and non-specific effects of cigarette smoking on endogenous opioid mechanisms.Progress in neuro-psychopharmacology & biological psychiatry · 2016Article
- Attentional bias to smoking and other motivationally relevant cues is affected by nicotine exposure and dose expectancy.Journal of psychopharmacology (Oxford, England) · 2016Article
- Withdrawal: Expanding a Key Addiction Construct.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Review
- Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans.Neuropharmacology · 2014Review
- Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Neuroimaging in Alcohol and Drug Dependence.Current behavioral neuroscience reports · 2014Article
- Elevation of dopamine induced by cigarette smoking: novel insights from a [11C]-+-PHNO PET study in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Effects of smoking on D₂/D₃ striatal receptor availability in alcoholics and social drinkers.Brain imaging and behavior · 2013Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
introductionNicotine has long been recognized as a necessary but insufficient component of tobacco cigarettes to maintain a psychophysiological need to smoke. This study examined venous plasma concentrations effects of nicotine in cigarette smoking after overnight abstinence to release striatal dopamine (DA).
methodsTwenty-two male smokers smoked either denicotinized (denic) or average nicotine (nic) cigarettes under single blind conditions. Each was given [(11)C]raclopride and scanned in a positron emission tomography (PET) facility.
resultsSmoking either denic or nic cigarettes released striatal DA. Denic cigarette smoking released DA primarily in the right striatum, whereas nic cigarette smoking released DA in both striata, but especially in the left. Increases in venous plasma nicotine concentrations correlated positively with increased DA release in the left caudate nucleus. Smoking denic cigarettes reduced craving as much as smoking nic cigarettes. Craving reduction after nic tobacco smoking correlated with increases in plasma nicotine.
conclusionsNonnicotine factors in tobacco smoking produce important right brain effects. Nicotine is a pharmacological factor during tobacco smoking that releases bilateral striatal DA, but more in the left brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.