Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2013
Local infusion analgesia using intra-articular double lumen catheter after total knee arthroplasty: a double blinded randomized control study.
Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Effectiveness and weakness of local infiltration analgesia in total knee arthroplasty: a systematic review.The Journal of international medical research · 2018Pooled it
- Pooled it
- Periarticular multimodal drug injection in total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Pooled it
- Percutaneous periarticular analgesic injection at one day after simultaneous bilateral total knee arthroplasty: an open-label randomized control trial.Journal of orthopaedic surgery and research · 2021Trial
- Percutaneous periarticular multi-drug injection at one day after total knee arthroplasty as a component of multimodal pain management: a randomized control trial.BMC musculoskeletal disorders · 2019Trial
- Trial
- Effects of dexamethasone on local infiltration analgesia in total knee arthroplasty: a randomized controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014Trial
- A Collaborative Multimodal Pain Management Pathway Reduces Opiate Consumption After Total Hip and Knee Arthroplasty.Arthroplasty today · 2025Article
- Analgesic efficacy of single-shot adductor canal block versus adductor canal block combined with intra-articular ropivacaine infusion after total knee arthroplasty.Bone & joint open · 2021Article
- C-reactive protein as marker of post-operative analgesic quality after primary total knee arthroplasty.International orthopaedics · 2020Article
- Benefit of subcutaneous patient controlled analgesia after total knee arthroplasty.Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology · 2019Article
- Enhanced recovery principles applied to revision hip and knee arthroplasty reduces length of stay and blood transfusion.Journal of orthopaedics · 2017Article
- Enhanced recovery principles applied to revision hip and knee arthroplasty leads to better patient outcomes.Journal of orthopaedicsArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough intra-operative local infiltration analgesia has gained increasing popularity in joint replacement surgery, it is not clear whether postoperative local infusion analgesia using an indwelling catheter provides clinically important additional effects. We, therefore, conducted a randomized controlled trial to clarify the efficacy of the originally developed local infusion analgesia technique in total knee arthroplasty.
methodsForty patients were randomly allocated to the local infusion analgesia or control group. Patients in the local infusion analgesia group received intermittent bolus intra-articular injection of analgesics consisting of ropivacaine, dexamethasone, and isepamicin until postoperative 48 h. Primary outcome was pain severity at rest using 100-mm visual analogue scale.
resultsPain severity in patients of the local infusion analgesia group was lower than control group, and there were significant differences between groups at POD1 (p = 0.025) and POD3 (p = 0.007). Reduction of postoperative pain was associated with a decrease in C-reactive protein level and earlier achievement of straight leg raise. In addition, postoperative drain volume was reduced in the local infusion analgesia group.
conclusionAlthough larger studies are needed to examine its safety, the local infusion analgesia alone provided clinically significant analgesic effects and rapid recovery in total knee arthroplasty.
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