ArticleMolecules (Basel, Switzerland)2012
Bio-functional constituents from the stems of Liriodendron tulipifera.
Article in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
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- Cytotoxic compounds from the leaves and stems of the endemic Thai plantPharmaceutical biology · 2020Article
- The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling.Oxidative medicine and cellular longevity · 2020Article
- Exploring new applications of tulip tree (Liriodendron tulipifera L.): leaf essential oil as apoptotic agent for human glioblastoma.Environmental science and pollution research international · 2019Article
- Liriodenine enhances radiosensitivity in esophageal cancer ECA-109 cells by inducing apoptosis and GOncology letters · 2018Article
- Silencing Stem Cell Factor Gene in Fibroblasts to Regulate Paracrine Factor Productions and Enhance c-Kit Expression in Melanocytes on Melanogenesis.International journal of molecular sciences · 2018Article
- Xylopine Induces Oxidative Stress and Causes GOxidative medicine and cellular longevity · 2017Article
- Cytotoxic Alkaloids from the Stem of Xylopia laevigata.Molecules (Basel, Switzerland) · 2016Article
- 4-(Phenylsulfanyl)butan-2-One Suppresses Melanin Synthesis and Melanosome Maturation In Vitro and In Vivo.International journal of molecular sciences · 2015Article
- Glaucine inhibits breast cancer cell migration and invasion by inhibiting MMP-9 gene expression through the suppression of NF-κB activation.Molecular and cellular biochemistry · 2015Article
- Liriodenine induces the apoptosis of human laryngocarcinoma cells via the upregulation of p53 expression.Oncology letters · 2015Article
- Antioxidant and anticancer constituents from the leaves of Liriodendron tulipifera.Molecules (Basel, Switzerland) · 2014Article
- Biofunctional constituents from Liriodendron tulipifera with antioxidants and anti-melanogenic properties.International journal of molecular sciences · 2013Article
- Antimelanoma and antityrosinase from Alpinia galangal constituents.TheScientificWorldJournal · 2013Article
- Zanthoxoaporphines A-C: Three new larvicidal dibenzo[de,g]quinolin-7-one alkaloids from Zanthoxylum paracanthum (Rutaceae).Beilstein journal of organic chemistry · 2013Article
- Biological properties of acidic cosmetic water from seawater.International journal of molecular sciences · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Four known compounds have been isolated from the stems of Liriodendron tulipifera, and the structures of these pure constituents were determined using spectroscopic analysis. Isolated compounds were screened for free radical scavenging ability, metal chelating power assay and ferric reducing antioxidant power assay (FRAP). The anti-tyrosinase effects of L. tulipifera compounds were calculated the inhibition of hydroxylation of L-tyrosine to L-dopa according to an in vitro mushroom tyrosinase assay. The study also examined the bio-effects of the four compounds on the human melanoma A375.S2, and showed that liriodenine (1) and (-)-norglaucine (4) significantly inhibited the proliferation of melanoma cells in the cell viability assay. Wound healing results indicated that liriodenine (1), (-)-glaucine (3) and (-)-norglaucine (4) exerted anti-migration potential. Interestingly, (-)-glaucine (3), neither liriodenine (1) nor (-)-norglaucine (4) showed promising anti-migration potential without inducing significant cytotoxicity. Furthermore, a dramatically increased level of intracellular reactive oxygen species (ROS) was detected from (-)-glaucine (3). The cell cycle assessment demonstrated a moderate G2/M accumulation by (-)-glaucine (3). The above results revealed the anti-cancer effects of L. tulipifera compounds, especially on the anti-migration ability indicating the promising chemopreventive agents to human skin melanoma cells.
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