ArticleCancer research2012
In vivo diagnosis of melanoma and nonmelanoma skin cancer using oblique incidence diffuse reflectance spectrometry.
Article in Cancer research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Diagnostic Accuracy of Novel Optical Imaging Techniques for Melanoma Detection: A Systematic Review and Meta-Analysis.International journal of dermatology · 2025Pooled it
- Comparative Analysis of Diagnostic Techniques for Melanoma Detection: A Systematic Review of Diagnostic Test Accuracy Studies and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Computer-assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Noninvasive optical spectroscopy for identification of non-melanoma skin cancer: Pilot study.Lasers in surgery and medicine · 2018Trial
- Biophotonics point-of-care diagnostics in low-resource settings: a South African perspective.Journal of biomedical optics · 2026Review
- Terahertz Mie scattering in tissue: diffuse polarimetric imaging and Monte Carlo validation in highly attenuating media models.Journal of biomedical optics · 2025Article
- Laser speckle size and contrast investigation of volumetric scattering from controlled turbid phantoms and mouse skin tissues.iScience · 2025Article
- Machine learning-based classification of spatially resolved diffuse reflectance and autofluorescence spectra acquired on human skin for actinic keratoses and skin carcinoma diagnostics aid.Journal of biomedical optics · 2025Article
- Quantitative estimation of optical properties in bilayer media within the subdiffusive regime using tilted fiber-optic probe diffuse reflectance spectroscopy, part 2: probe design, realization, and experimental validation.Journal of biomedical optics · 2024Article
- Multimodal Method for Differentiating Various Clinical Forms of Basal Cell Carcinoma and Benign Neoplasms In Vivo.Diagnostics (Basel, Switzerland) · 2024Article
- Portable Diffuse Reflectance Spectroscopy of Potato Leaves for Pre-Symptomatic Detection of Late Blight Disease.Applied spectroscopy · 2023Article
- Motionless volumetric structured light sheet microscopy.Biomedical optics express · 2023Article
- Polarization memory rate as a metric to differentiate benign and malignant tissues.Biomedical optics express · 2022Article
- Constructing a portable optical polarimetry probe for in-vivo skin cancer detection.Journal of biomedical optics · 2021Article
- Differentiation of skin biopsies by light scattering spectroscopy.Postepy dermatologii i alergologii · 2020Article
- Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models.Cancers · 2020Article
- Visible near infrared reflectance molecular chemical imaging of human ex vivo carcinomas and murine in vivo carcinomas.Journal of biomedical optics · 2020Article
- A roadmap for the clinical implementation of optical-imaging biomarkers.Nature biomedical engineering · 2019Review
- Light scattering methods for tissue diagnosis.Optica · 2019Article
- Challenges and opportunities in clinical translation of biomedical optical spectroscopy and imaging.Journal of biomedical optics · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Early detection and treatment of skin cancer can significantly improve patient outcome. However, present standards for diagnosis require biopsy and histopathologic examinations that are relatively invasive, expensive, and difficult for patients with many early-stage lesions. Here, we show an oblique incidence diffuse reflectance spectroscopic (OIDRS) system that can be used for rapid skin cancer detection in vivo. This system was tested under clinical conditions by obtaining spectra from pigmented and nonpigmented skin lesions, including melanomas, differently staged dysplastic nevi, and common nevi that were validated by standard pathohistologic criteria. For diagnosis of pigmented melanoma, the data obtained achieved 90% sensitivity and specificity for a blinded test set. In a second analysis, we showed that this spectroscopy system can also differentiate nonpigmented basal cell or squamous cell carcinomas from noncancerous skin abnormalities, such as actinic keratoses and seborrheic keratoses, achieving 92% sensitivity and specificity. Taken together, our findings establish how OIDRS can be used to more rapidly and easily diagnose skin cancer in an accurate and automated manner in the clinic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.