ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2012
Features of infections due to Klebsiella pneumoniae carbapenemase-producing Escherichia coli: emergence of sequence type 131.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 53 citations in OpenAlex.
- International Epidemiology of Carbapenemase-Producing Escherichia coli.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Klebsiella pneumoniae carbapenamases in Escherichia coli isolated from humans and livestock in rural south-western Uganda.PloS one · 2023Article
- Clinical Impact of Colistin Banning in Food Animal onFrontiers in microbiology · 2022Article
- Prevalence and Molecular Epidemiology of Extended-Spectrum-β-Lactamase (ESBL)-ProducingAnnals of laboratory medicine · 2021Article
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- Emergence of a ClinicalFrontiers in microbiology · 2020Article
- Characterization of a Multidrug-Resistant Porcine Klebsiella pneumoniae Sequence Type 11 Strain CoharboringmSphere · 2019Article
- Detection of high-risk carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates using volatile molecular profiles.Scientific reports · 2018Article
- Diversity among blaScientific reports · 2018Article
- The use of SWATH to analyse the dynamic changes of bacterial proteome of carbapanemase-producing Escherichia coli under antibiotic pressure.Scientific reports · 2018Article
- Draft Genome Sequences ofGenome announcements · 2018Article
- High-Resolution Melting Analysis for Rapid Detection of Sequence Type 131 Escherichia coli.Antimicrobial agents and chemotherapy · 2017Article
- Emergence of NDM-5- and MCR-1-Producing Escherichia coli Clones ST648 and ST156 from a Single Muscovy Duck (Cairina moschata).Antimicrobial agents and chemotherapy · 2016Article
- The role of epidemic resistance plasmids and international high-risk clones in the spread of multidrug-resistant Enterobacteriaceae.Clinical microbiology reviews · 2015Review
- Tackling Drug Resistant Infection Outbreaks of Global Pandemic Escherichia coli ST131 Using Evolutionary and Epidemiological Genomics.Microorganisms · 2015Review
- Pediatric carbapenem-resistant Enterobacteriaceae in Los Angeles, California, a high-prevalence region in the United States.The Pediatric infectious disease journal · 2015Article
- Plasmid flux in Escherichia coli ST131 sublineages, analyzed by plasmid constellation network (PLACNET), a new method for plasmid reconstruction from whole genome sequences.PLoS genetics · 2014Article
- Molecular features of community-associated extended-spectrum-β-lactamase-producing Escherichia coli strains in the United States.Antimicrobial agents and chemotherapy · 2014Article
- Complete sequence of a conjugative incn plasmid harboring blaKPC-2, blaSHV-12, and qnrS1 from an Escherichia coli sequence type 648 strain.Antimicrobial agents and chemotherapy · 2014Article
- Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system.Diagnostic microbiology and infectious disease · 2014Article
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6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundKlebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become endemic in many US hospitals. On the other hand, KPC-producing Escherichia coli remains rare.
methodsWe studied infection or colonization due to KPC-producing E. coli identified at our hospital between September 2008 and February 2011. A case-control study was conducted to document clinical features associated with this organism. Susceptibility testing, sequencing of β-lactamase genes, pulsed-field gel electrophoresis, multilocus sequence typing, and plasmid analysis were performed for characterization of the isolates.
resultsThirteen patients with KPC-producing E. coli were identified. The patients had multiple comorbid conditions and were in hospital for variable periods of time before KPC-producing E. coli was identified. The presence of liver diseases was independently associated with recovery of KPC-producing E. coli when compared with extended-spectrum β-lactamase-producing E. coli. The isolates showed variable susceptibility to carbapenems. Seven isolates belonged to sequence type (ST) 131, which is the international epidemic, multidrug-resistant clone, but their plasmid profiles were diverse. KPC-producing organisms other than E. coli were isolated within 1 month from 5 of the patients. The KPC-encoding plasmids were highly related in 3 of them, suggesting the occurrence of their interspecies transfer.
conclusionsKPC-producing E. coli infections occur in severely ill patients who are admitted to the hospital. Acquisition of the KPC-encoding plasmids by the ST 131 clone, reported here for the first time to our knowledge in the United States, seems to represent multiple independent events. These plasmids are often shared between E. coli and other species.
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