ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2012
Evolution of vertebrate tissues driven by differential modes of gene duplication.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Promoter evolution of mammalian gene duplicates.BMC biology · 2023Article
- Region-specific expression of young small-scale duplications in the human central nervous system.BMC ecology and evolution · 2021Article
- Article
- AMPK: An Epigenetic Landscape Modulator.International journal of molecular sciences · 2018Review
- Functional divergence of duplicate genes several million years after gene duplication in Arabidopsis.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Selective Constraints on Coding Sequences of Nervous System Genes Are a Major Determinant of Duplicate Gene Retention in Vertebrates.Molecular biology and evolution · 2017Article
- Global analysis of human duplicated genes reveals the relative importance of whole-genome duplicates originated in the early vertebrate evolution.BMC genomics · 2016Article
- Article
- Relationship between gene duplicability and diversifiability in the topology of biochemical networks.BMC genomics · 2014Article
- Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers.Open biology · 2014Article
- Effect of IRS4 levels on PI 3-kinase signalling.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we investigated the evolution of vertebrate tissues by examining the potential association among gene expression, duplication, and base substitution patterns. In particular, we compared whole-genome duplication (WGD) with small-scale duplication (SSD), as well as tissue restricted with ubiquitously expressed genes. All patterns were also analysed in the light of gene evolutionary rates. Among those genes characterized by rapid evolution and expressed in a restricted range of tissues, SSD was represented in a larger proportion than WGD. Conversely, genes with ubiquitous expression were associated with slower evolutionary rates and a larger proportion of WGD. The results also show that evolutionary rates were faster in genes expressed in endodermal tissues and slower in ectodermal genes. Accordingly, the proportion of the SSD and WGD genes was highest in the endoderm and ectoderm, respectively. Therefore, quickly evolving SSD genes might have contributed to the faster evolution of endodermal tissues, whereas the comparatively slowly evolving WGD genes might have functioned to maintain the basic characteristics of ectodermal tissues. Mesenchymal tissues occupied an intermediate position in this regard, whereas the patterns observed for haemocytes were unique. Rapid tissue evolution could be related to a specific gene duplication mode (SSD) and faster molecular evolution in response to exposure to the external environment. These findings reveal general patterns underlying the evolution of tissues and their corresponding genes.
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Registered trials
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