Evidence map›Paper›PMID 22490883›Full record

ArticleNeuroscience letters2012

AMPA receptor subunit expression in the cuneate nucleus of adult squirrel monkeys after peripheral nerve injury.

Rohini M Sarin, Todd M Mowery, Preston E Garraghty

Open access · greenAbstract read
In one paragraph

Article in Neuroscience letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rohini M SarinDepartment of Biology, Indiana University, Bloomington, IN, USA.
Todd M Mowery
Preston E Garraghty
Indiana University Bloomington · US

Funding

MECHANISMS OF PLASTICITY IN THE ADULT PRIMATE BRAINR01NS037348 · NINDS · INDIANA UNIVERSITY BLOOMINGTON · PI GARRAGHTY, PRESTON E. · 1999 to 2002
$522k
NINDS NIH HHS NS37348NINDS NIH HHS R01 NS037348
6 · The paper itself

Abstract

The primate somatosensory system provides an excellent model system with which to investigate adult neural plasticity. Here, we report immunohistochemical staining data for the GluR1 and GluR2/3 AMPA receptor subunits in the cuneate nucleus of adult squirrel monkeys one week after median nerve compression. These data are compared to subunit changes in the area 3b cortex of the same animals. We report differences between control and deprived brainstem implying that deprivation induced changes in subunit expression mirror those reported in the cortex. There are significant increases in GluR1 receptor subunit staining intensity and significant decreases in GluR2/3 receptor subunit staining intensity. This pattern of expression resembles receptor configurations reported in developing sensory systems. Taken together, these results suggest that the brainstem and the cortex initially progress through a phase of developmental recapitulation prior to the onset of NMDA mediated adult somatosensory reorganization.

Indexed as

AnimalsImmunohistochemistryMedulla OblongataNeuronal PlasticityPeripheral Nerve InjuriesProtein SubunitsReceptors, AMPASaimiriSomatosensory CortexProtein SubunitsReceptors, AMPA

Identifiers

PMID22490883
PMCPMC4106283
OpenAlexW2079703358

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.