ArticleMolecular biology and evolution2012
Adaptive evolution and effective population size in wild house mice.
Article in Molecular biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 84 citations in OpenAlex.
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- Purifying Selection Influences the Comparison of Heterozygosities between Populations.Biology · 2024Article
- The Evolutionary Interplay of Somatic and Germline Mutation Rates.Annual review of biomedical data science · 2024Review
- Biases in ARG-Based Inference of Historical Population Size in Populations Experiencing Selection.Molecular biology and evolution · 2024Article
- Dominant constraints on the evolution of rhythmic gene expression.Computational and structural biotechnology journal · 2023Article
- House mouse subspecies do differ in their social structure.Ecology and evolution · 2022Article
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- Chromosome size affects sequence divergence between species through the interplay of recombination and selection.Evolution; international journal of organic evolution · 2022Article
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- Mammalian circular RNAs result largely from splicing errors.Cell reports · 2021Article
- The rate and molecular spectrum of mutation are selectively maintained in yeast.Nature communications · 2021Article
- Characterizing patterns of genomic variation in the threatened Utah prairie dog: Implications for conservation and management.Evolutionary applications · 2021Article
- Greater strength of selection and higher proportion of beneficial amino acid changing mutations in humans compared with mice andGenome research · 2021Article
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- Higher Germline Mutagenesis of Genes with Stronger Testis Expressions Refutes the Transcriptional Scanning Hypothesis.Molecular biology and evolution · 2020Article
- Mitochondrial genomics reveals the evolutionary history of the porpoises (Phocoenidae) across the speciation continuum.Scientific reports · 2020Article
- Population Genomics of the House Mouse and the Brown Rat.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Comparison of the Full Distribution of Fitness Effects of New Amino Acid Mutations Across Great Apes.Genetics · 2019Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
Estimates of the proportion of amino acid substitutions that have been fixed by selection (α) vary widely among taxa, ranging from zero in humans to over 50% in Drosophila. This wide range may reflect differences in the efficacy of selection due to differences in the effective population size (N(e)). However, most comparisons have been made among distantly related organisms that differ not only in N(e) but also in many other aspects of their biology. Here, we estimate α in three closely related lineages of house mice that have a similar ecology but differ widely in N(e): Mus musculus musculus (N(e) ∼ 25,000-120,000), M. m. domesticus (N(e) ∼ 58,000-200,000), and M. m. castaneus (N(e) ∼ 200,000-733,000). Mice were genotyped using a high-density single nucleotide polymorphism array, and the proportions of replacement and silent mutations within subspecies were compared with those fixed between each subspecies and an outgroup, Mus spretus. There was significant evidence of positive selection in M. m. castaneus, the lineage with the largest N(e), with α estimated to be approximately 40%. In contrast, estimates of α for M. m. domesticus (α = 13%) and for M. m. musculus (α = 12 %) were much smaller. Interestingly, the higher estimate of α for M. m. castaneus appears to reflect not only more adaptive fixations but also more effective purifying selection. These results support the hypothesis that differences in N(e) contribute to differences among species in the efficacy of selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.