ArticleCerebral cortex (New York, N.Y. : 1991)2013
EphA signaling impacts development of topographic connectivity in auditory corticofugal systems.
Article in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Absolute pitch exhibits phenotypic and genetic overlap with synesthesia.Human molecular genetics · 2013Trial
- Eph and ephrin signaling in the development of the central auditory system.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Corticofugal regulation of predictive coding.eLife · 2022Article
- Segregation of Multimodal Inputs Into Discrete Midbrain Compartments During an Early Critical Period.Frontiers in neural circuits · 2022Article
- Patterns of Unilateral and Bilateral Projections From Layers 5 and 6 of the Auditory Cortex to the Inferior Colliculus in Mouse.Frontiers in systems neuroscience · 2021Article
- GABAJournal of neurophysiology · 2020Article
- Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections.Frontiers in neural circuits · 2020Review
- Shaping of discrete auditory inputs to extramodular zones of the lateral cortex of the inferior colliculus.Brain structure & function · 2019Article
- Article
- Precision in the development of neocortical architecture: From progenitors to cortical networks.Progress in neurobiology · 2019Review
- Alignment of EphA4 and ephrin-B2 expression patterns with developing modularity in the lateral cortex of the inferior colliculus.The Journal of comparative neurology · 2018Article
- Sensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage.Nature communications · 2018Article
- Modular-extramodular organization in developing multisensory shell regions of the mouse inferior colliculus.The Journal of comparative neurology · 2017Article
- Anatomical characterization of subcortical descending projections to the inferior colliculus in mouse.The Journal of comparative neurology · 2017Article
- EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development.The Journal of comparative neurology · 2016Article
- Differential maturation of vesicular glutamate and GABA transporter expression in the mouse auditory forebrain during the first weeks of hearing.Brain structure & function · 2016Article
- Graded and discontinuous EphA-ephrinB expression patterns in the developing auditory brainstem.Hearing research · 2016Article
- Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons.Neural development · 2015Article
- Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders.Behavioural brain research · 2015Article
- Axon guidance in the auditory system: multiple functions of Eph receptors.Neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Auditory stimulus representations are dynamically maintained by ascending and descending projections linking the auditory cortex (Actx), medial geniculate body (MGB), and inferior colliculus. Although the extent and topographic specificity of descending auditory corticofugal projections can equal or surpass that of ascending corticopetal projections, little is known about the molecular mechanisms that guide their development. Here, we used in utero gene electroporation to examine the role of EphA receptor signaling in the development of corticothalamic (CT) and corticocollicular connections. Early in postnatal development, CT axons were restricted to a deep dorsal zone (DDZ) within the MGB that expressed low levels of the ephrin-A ligand. By hearing onset, CT axons had innervated surrounding regions of MGB in control-electroporated mice but remained fixed within the DDZ in mice overexpressing EphA7. In vivo neurophysiological recordings demonstrated a corresponding reduction in spontaneous firing rate, but no changes in sound-evoked responsiveness within MGB regions deprived of CT innervation. Structural and functional CT disruption occurred without gross alterations in thalamocortical connectivity. These data demonstrate a potential role for EphA/ephrin-A signaling in the initial guidance of corticofugal axons and suggest that "genetic rewiring" may represent a useful functional tool to alter cortical feedback without silencing Actx.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.