ArticleGut2013
Serrated polyposis: rapid and relentless development of colorectal neoplasia.
Article in Gut, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guideline
- British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.Gut · 2017Guideline
- Usefulness of narrow-band imaging for the detection of remnant sessile-serrated adenoma (SSA) tissue after endoscopic resection: the KASID multicenter study.Surgical endoscopy · 2021Trial
- Gastrointestinal Tract Polyp Detection, Tracking, and Surveillance and the Role of Artificial Intelligence.Cureus · 2026Review
- Key genes and pathway differences between serrated polyps and conventional adenomas: insights from multi-omics.Translational cancer research · 2026Article
- The histologic features, molecular features, detection and management of serrated polyps: a review.Frontiers in oncology · 2024Review
- Feasibility and Safety of Endoscopic Control for Patients with Serrated Polyposis Syndrome.Digestive diseases (Basel, Switzerland) · 2024Article
- Serrated Colorectal Lesions: An Up-to-Date Review from Histological Pattern to Molecular Pathogenesis.International journal of molecular sciences · 2022Review
- Discovering the Mutational Profile of Early Colorectal Lesions: A Translational Impact.Cancers · 2021Review
- Article
- Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review).International journal of molecular medicine · 2021Article
- Novel Genetic Causes of Gastrointestinal Polyposis Syndromes.The application of clinical genetics · 2021Review
- Optimal Endoscopic Treatment and Surveillance of Serrated Polyps.Gut and liver · 2020Review
- An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Review
- CpG Island Methylation in Sessile Serrated Adenoma/Polyp of the Colorectum: Implications for Differential Diagnosis of Molecularly High-Risk Lesions among Non-dysplastic Sessile Serrated Adenomas/Polyps.Journal of pathology and translational medicine · 2019Article
- Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis.Intestinal research · 2018Review
- Serrated Polyps of Colon and Rectum: a Clinicopathologic Review.Journal of gastrointestinal cancer · 2017Review
- Sessile Serrated Adenomas: How to Detect, Characterize and Resect.Gut and liver · 2017Review
- Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management.The American journal of gastroenterology · 2017Review
- Clinical characteristics of patients with serrated polyposis syndrome in Korea: comparison with Western patients.Intestinal research · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveSerrated (hyperplastic) polyposis (SP) is a rare disorder with multiple colorectal hyperplastic polyps and often sessile serrated adenomas/polyps (SSA/P) or adenomas. Although associated with colorectal cancer, the course of SP is not well described.
design44 patients with SP were studied. The results of 146 colonoscopies with median follow-up of 2.0 years (range 0-30) and a median of 1.0 years (range 0.5-6) between surveillance colonoscopies were evaluated. Findings from oesophogastroduodenoscopy examinations were analysed.
resultsThe mean age at diagnosis of SP was 52.5 ± 11.9 years (range 22-78). In two pedigrees (5%) another family member had SP. None of 22 patients had gastroduodenal polyps. All patients had additional colorectal polyps at surveillance colonoscopy. SSA/P or adenomas were found in 25 patients (61%) at first colonoscopy and 83% at last colonoscopy. Recurrent SSA/P or adenomas occurred in 68% of patients at surveillance colonoscopy. Three patients had colorectal cancer. Eleven patients (25%) underwent surgery (mean time from diagnosis of SP 2.0 ± 0.9 years). After surgery all seven surveyed patients developed recurrent polyps in the retained colorectum (4/7 had SSA/P or adenomas). No association was found between colorectal neoplasia and sex, age at diagnosis of SP or initial number of colorectal polyps.
conclusionsIn SP, rapid and unrelenting colorectal neoplasia development continues in the intact colorectum and retained segment after surgery. These findings support the possibility of annual colonoscopic surveillance, consideration for colectomy when SSA/P or adenomas are encountered and frequent postoperative endoscopic surveillance of the retained colorectum.
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Registered trials
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