ArticlePeptides2012
Divergent pathways for the angiotensin-(1-12) metabolism in the rat circulation and kidney.
Article in Peptides, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- 2020 update on the renin-angiotensin-aldosterone system in pediatric kidney disease and its interactions with coronavirus.Pediatric nephrology (Berlin, Germany) · 2021Review
- Angiotensin (1-12) in Humans With Normal Blood Pressure and Primary Hypertension.Hypertension (Dallas, Tex. : 1979) · 2021Article
- An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology.Journal of cardiovascular development and disease · 2019 · on this mapReview
- Nicotine and the renin-angiotensin system.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Review
- Intra-Renal Angiotensin Levels Are Increased in High-Fructose Fed Rats in the Extracorporeal Renal Perfusion Model.Frontiers in physiology · 2018Article
- Urinary Proteome Analysis Identified Neprilysin and VCAM as Proteins Involved in Diabetic Nephropathy.Journal of diabetes research · 2018Article
- Measurement of Angiotensin Peptides: HPLC-RIA.Methods in molecular biology (Clifton, N.J.) · 2017Review
- Therapeutic Approaches to the Alternative Angiotensin-(1-7) Axis of the Renin-Angiotensin System.Annals of pharmacology and pharmaceutics · 2017Article
- Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-( 1-12) Axis in the Pathogenesis of Diabetic Retinopathy.Current medicinal chemistry · 2017Review
- Intracrine angiotensin II functions originate from noncanonical pathways in the human heart.American journal of physiology. Heart and circulatory physiology · 2016Review
- Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?American journal of physiology. Heart and circulatory physiology · 2016Review
- The compensatory renin-angiotensin system in the central regulation of arterial pressure: new avenues and new challenges.Therapeutic advances in cardiovascular disease · 2015Review
- Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1-7) and Bradykinin.Journal of diabetes research · 2015Article
- Angiotensin-[1-12] interacts with angiotensin type I receptors.Neuropharmacology · 2014Article
- Is the renin-angiotensin system actually hypertensive?Pediatric nephrology (Berlin, Germany) · 2014Review
- Subfractionation, characterization, and in-depth proteomic analysis of glomerular membrane vesicles in human urine.Kidney international · 2014Article
- Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate.Current hypertension reports · 2014Review
- An evolving story of angiotensin-II-forming pathways in rodents and humans.Clinical science (London, England : 1979) · 2014Review
- Update on the Angiotensin converting enzyme 2-Angiotensin (1-7)-MAS receptor axis: fetal programing, sex differences, and intracellular pathways.Frontiers in endocrinology · 2014Review
- Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism.American journal of physiology. Heart and circulatory physiology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Evidence of endogenous angiotensin-(1-12) [Ang-(1-12)] may necessitate revision of the accepted view that Ang I is the immediate peptide product derived from the precursor protein angiotensinogen. As the processing of this peptide has not been fully elucidated, we characterized Ang-(1-12) metabolism in the serum and kidney of the mRen2.Lewis rat, a model of high circulating renin and ACE expression. A sensitive HPLC-based method to detect the metabolism ex vivo of low concentrations of (125)I-labeled Ang-(1-12) was utilized. Ang-(1-12) processing to serum did not reveal the participation of renin; however, serum ACE readily converted Ang-(1-12) to Ang I with subsequent metabolism to Ang II. Ang I and Ang II forming activities for serum ACE were 102±4 and 104±3 fmol/ml/min serum (n=3), respectively, and both products were abolished by the potent ACE inhibitor lisinopril. The metabolism of Ang-(1-12) in renal cortical membranes also revealed the formation of Ang I; however, the main products were Ang-(1-7) and Ang-(1-4) at 129±9 and 310±12 fmol/mg/min protein (n=4), respectively. Neprilysin inhibition abolished these products and substantially reduced the overall metabolism of Ang-(1-12). Incubation of Ang-(1-12) with either human or mouse neprilysin revealed identical products. We conclude that endogenous Ang-(1-12) may contribute to the expression of biologically active angiotensins through a renin-independent pathway. The preferred route for Ang-(1-12) metabolism likely reflects the relative tissue content of ACE and neprilysin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.