ArticleBMC gastroenterology2012
A retrospective case-control study of hepatitis C virus infection and oral lichen planus in Japan: association study with mutations in the core and NS5A region of hepatitis C virus.
Article in BMC gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 43 citations in OpenAlex.
- History of Breast Cancer in Patients with Oral Lichen Planus: A Case-Control Study.Journal of clinical medicine · 2024Article
- Bidirectional Association between Lichen Planus and Hepatitis C-An Update Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Risk of Prediabetes and Diabetes in Oral Lichen Planus: A Case-Control Study according to Current Diagnostic Criteria.Diagnostics (Basel, Switzerland) · 2023Article
- Lichen planus in Germany - epidemiology, treatment, and comorbidity. A retrospective claims data analysis.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2022Observational
- Oral lichen planus: a microbiologist point of view.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Review
- The role of dentists in controlling hepatocellular carcinoma in Japan (Review).Experimental and therapeutic medicine · 2021Review
- Lack of Association between Oral Lichen Planus and Hepatitis B and C Virus Infection - a Report from Southeast IranAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Oral Lichen Planus: an Overview of Potential Risk Factors, Biomarkers and TreatmentsAsian Pacific journal of cancer prevention : APJCP · 2018Review
- Lack of evidence of hepatitis in patients with oral lichen planus in China: A case control study.Medicina oral, patologia oral y cirugia bucal · 2016Article
- A review of the burden of hepatitis C virus infection in China, Japan, South Korea and Taiwan.Hepatology international · 2015Review
- Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases.BMC gastroenterology · 2012Article
- Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Observational descriptive study of cutaneous manifestations in patients from Mato Grosso with viral chronic hepatitis.Anais brasileiros de dermatologiaObservational
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aims of this study were to assess the prevalence of hepatitis C virus (HCV) infection in Japanese patients with oral lichen planus and identify the impact of amino acid (aa) substitutions in the HCV core region and IFN-sensitivity-determining region (ISDR) of nonstructural protein 5A (NS5A) associated with lichen planus.
methodsIn this retrospective study, 59 patients (group 1-A) with oral lichen planus among 226 consecutive patients who visited our hospital and 85 individuals (group 1-B, controls) with normal oral mucosa were investigated for the presence of liver disease and HCV infection. Risk factors for the presence of oral lichen planus were assessed by logistic regression analysis. We compared aa substitutions in the HCV core region (70 and/or 91) and ISDR of NS5A of 12 patients with oral lichen planus (group 2-A) and 7 patients who did not have oral lichen planus (group 2-B) among patients (high viral loads, genotype 1b) who received interferon (IFN) therapy in group1-A.
resultsThe prevalence of anti-HCV and HCV RNA was 67.80% (40/59) and 59.32% (35/59), respectively, in group 1-A and 31.76% (27/85) and 16.47% (14/85), respectively, in group 1-B. The prevalence of anti-HCV (P < 0.0001) and HCV RNA (P < 0.0001) in group 1-A was significantly higher than those in group 1-B. According to multivariate analysis, three factors - positivity for HCV RNA, low albumin level (< 4.0 g/dL), and history of smoking - were associated with the development of oral lichen planus. The adjusted odds ratios for these three factors were 6.58, 3.53 and 2.58, respectively, and each was statistically significant. No significant differences in viral factors, such as aa substitutions in the core region and ISDR of NS5A, were detected between the two groups (groups 2-A and -B).
conclusionWe observed a high prevalence of HCV infection in patients with oral lichen planus. Longstanding HCV infection, hypoalbuminemia, and smoking were significant risk factors for the presence of oral lichen planus in patients. It is advisable for Japanese patients with lichen planus to be tested for HCV infection during medical examination.
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