ArticleInternational journal of vascular medicine2012
Varicose veins: role of mechanotransduction of venous hypertension.
Article in International journal of vascular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Non-coding RNAs in peripheral vascular diseases - a snRNA study.Journal of applied genetics · 2026Article
- Review
- Venocentric perspective on varicocele: summarizing mechanisms and explorations.Frontiers in physiology · 2026Review
- Monoamine oxidases are mediators of oxidative stress in human varicose Veins: interactions with obesity, inflammation, and angiotensin II.Molecular and cellular biochemistry · 2026Article
- Innovative Approaches and Future Directions in the Management and Understanding of Varicose Veins: A Systematic Review.ACS pharmacology & translational science · 2024Review
- Clinical evidence and rationale of mesoglycan to treat chronic venous disease and hemorrhoidal disease: a narrative review.Updates in surgery · 2024Review
- Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs.International journal of molecular sciences · 2024Review
- Relationship between internal diameter and vasoconstriction in human varicose veins.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2024Article
- Discovering Potential Compounds for Venous Disease Treatment through Virtual Screening and Network Pharmacology Approach.Molecules (Basel, Switzerland) · 2023Article
- Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management.Journal of clinical medicine · 2021Review
- Role of mechanosignaling on pathology of varicose vein.Biophysical reviews · 2021Review
- Hemodynamics mediated epigenetic regulators in the pathogenesis of vascular diseases.Molecular and cellular biochemistry · 2021Review
- Symptoms in Dilating Venous Disease.Current cardiology reviews · 2020Review
- Flow cytometric characterization of the saphenous veins endothelial cells in patients with chronic venous disease and in patients undergoing bypass surgery: an exploratory study.Heart and vessels · 2020Article
- Iris varix: 10-year experience with 28 eyes.Indian journal of ophthalmology · 2019Observational
- Chronic Venous Disorders: The Dangerous, the Good, and the Diverse.International journal of molecular sciences · 2018Article
- Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice.Frontiers in physiology · 2018Article
- Magnolol inhibits venous remodeling in mice.Scientific reports · 2017Article
- Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci.Scientific reports · 2017Article
- Characterization of regional deformation and material properties of the intact explanted vein by microCT and computational analysis.Cardiovascular engineering and technology · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Varicose veins affect approximately one-third of the adult population and result in significant psychological, physical, and financial burden. Nevertheless, the molecular pathogenesis of varicose vein formation remains unidentified. Venous hypertension exerted on veins of the lower extremity is considered the principal factor in varicose vein formation. The role of mechanotransduction of the high venous pressure in the pathogenesis of varicose vein formation has not been adequately investigated despite a good progress in understanding the mechanomolecular mechanisms involved in transduction of high blood pressure in the arterial wall. Understanding the nature of the mechanical forces, the mechanosensors and mechanotransducers in the vein wall, and the downstream signaling pathways will provide new molecular targets for the prevention and treatment of varicose veins. This paper summarized the current understanding of mechano-molecular pathways involved in transduction of hemodynamic forces induced by blood pressure and tries to relate this information to setting of venous hypertension in varicose veins.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.