Evidence map›Paper›PMID 22489120›Full record

ArticleInternational journal of molecular sciences2012

Molecular mechanisms of (R,R)ZX-5 on NO synthesis and its anti-angiogenic effect.

Li Pan, Jia-Liang Hu, Wen-Jing Wang, Xiao-Juan Zhang, Jin Wei, Zhen-Dong Liu, Yi-Hua Zhang, Han-Mei Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Li PanState Key Laboratory of Natural Medicines, College of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Jia-Liang HuState Key Laboratory of Natural Medicines, College of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Wen-Jing WangState Key Laboratory of Natural Medicines, College of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Xiao-Juan ZhangState Key Laboratory of Natural Medicines, College of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Jin WeiState Key Laboratory of Natural Medicines, College of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Zhen-Dong LiuState Key Laboratory of Natural Medicines, College of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
Yi-Hua ZhangDepartment of Pharmacy, University of China Pharmaceutical, Nanjing 210009, China.
Han-Mei XuState Key Laboratory of Natural Medicines, College of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(R,R)ZX-5 is a NO regulatory compound, which could significantly increase choroidal blood flow in New Zealand rabbit. The aim of this paper is to investigate the molecular mechanism of (R,R)ZX-5 promoting NO production. Besides this, we also investigated the antiangiogenic activity of (R,R)ZX-5. Analysis of Western blot showed that (R,R)ZX-5 up-regulated the expression of Akt, p-Akt (Thr473), eNOS and p-eNOS (Ser1177), down-regulated the expression of Cyclin D1 in human retinal endothelial cells and escalated the intracellular free Ca(2+) concentration. Additionally, (R,R)ZX-5 inhibited the growth of blood vessels in the chick chorioallantoic membrane model. It is concluded that (R,R)ZX-5 promotes choroidal blood flow through PI3K/Akt-eNOS and Akt-Ca(2+)-eNOS pathways. Additionally, (R,R)ZX-5 can inhibit angiogenesis.

Indexed as

Angiogenesis InhibitorsAniline CompoundsAnimalsBlotting, WesternCalciumCell LineChick EmbryoChorioallantoic MembraneChoroidCyclin D1Endothelial CellsHumansIntracellular SpaceNitric OxideNitric Oxide Synthase Type IIIPhosphorylation1-phenyl-3-(3-methoxy-2-propoxy-5-(4-(3,4,5-trimethoxyphenyl)-1,3-dithiolane-2-yl)phenyl)thioureaAngiogenesis InhibitorsAniline CompoundsCalciumCyclin D1Fluo-3Nitric OxideNitric Oxide Synthase Type IIIProto-Oncogene Proteins c-aktThioureaXanthenesage-related macular degenerationangiogenesischoroidal neovascularization(R,R)ZX-5signal pathways

Identifiers

PMID22489120
PMCPMC3317683
OpenAlexW2015240335

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.