ArticleAngewandte Chemie (International ed. in English)2012
An N-heterocyclic carbene/Lewis acid strategy for the stereoselective synthesis of spirooxindole lactones.
Article in Angewandte Chemie (International ed. in English), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 278 citations in OpenAlex.
- N-heterocyclic carbene catalyzed [2 + 3] annulation reaction for the synthesis of trifluoroethyl 3,2'-spirooxindole γ-lactam.RSC advances · 2024Article
- Multi-Component Syntheses of Spiro[furan-2,3'-indoline]-3-carboxylate Derivatives Using Ionic Liquid Catalysts.Molecules (Basel, Switzerland) · 2024Article
- Access to Spiropyrazolone-butenolides through NHC-Catalyzed [3 + 2]-Asymmetric Annulation of 3-Bromoenals and 1The Journal of organic chemistry · 2023Article
- Synthesis of tryptophan-containing 2,5-diketopiperazinesChemical science · 2021Article
- A Review of the Pharmacological Activities and Recent Synthetic Advances of γ-Butyrolactones.International journal of molecular sciences · 2021Review
- N-Heterocyclic carbene based catalytic platform for Hauser-Kraus annulations.Chemical science · 2020Article
- New Developments of the Principle of Vinylogy as Applied to π-Extended Enolate-Type Donor Systems.Chemical reviews · 2020Article
- Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs.Nature communications · 2019Article
- A Cooperative Ternary Catalysis System for Asymmetric Lactonizations of α-Ketoesters.Advanced synthesis & catalysis · 2017Article
- Recent Advances in the Synthesis of Spiroheterocycles via N-Heterocyclic Carbene Organocatalysis.Molecules (Basel, Switzerland) · 2017Review
- Reductive Coupling of Acrylates with Ketones and Ketimines by a Nickel-Catalyzed Transfer-Hydrogenative Strategy.Angewandte Chemie (International ed. in English) · 2017Article
- Catalytic Asymmetric Synthesis of Butenolides and Butyrolactones.Chemical reviews · 2017Review
- Molecular Hybridization-Guided One-Pot Multicomponent Synthesis of Turmerone Motif-Fused 3,3'-Pyrrolidinyl-dispirooxindoles via a 1,3-Dipolar Cycloaddition Reaction.Molecules (Basel, Switzerland) · 2017Article
- N-Heterocyclic carbene-catalyzed oxidative [3 + 2] annulation of dioxindoles and enals: cross coupling of homoenolate and enolate.Chemical science · 2017Article
- Highly Efficient Cascade Reaction for Selective Formation of Spirocyclobutenes from Dienallenes via Palladium-Catalyzed Oxidative Double Carbocyclization-Carbonylation-Alkynylation.Journal of the American Chemical Society · 2016Article
- Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes.Chemical reviews · 2015Review
- Carbene catalyzed umpolung of α,β-enals: a reactivity study of diamino dienolsChemical science · 2015Article
- N-Heterocyclic Carbene Catalyzed Enantioselective Annulation of Benzothiazolyl Ethyl Acetates with 2-Bromoenals.Synlett : accounts and rapid communications in synthetic organic chemistry · 2015Article
- Enantioselective β-Protonation by a Cooperative Catalysis Strategy.Journal of the American Chemical Society · 2015Article
- N-Heterocyclic carbene-catalyzed enantioselective annulations: a dual activation strategy for a formal [4+2] addition for dihydrocoumarins.Chemical communications (Cambridge, England) · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A cooperative catalysis approach for the enantioselective formal [3+2] addition of α,β-unsaturated aldehydes to isatins has been developed. Homoenolate annulations of β-aryl enals catalyzed by an N-heterocyclic carbene (NHC) require the addition of lithium chloride for high levels of enantioselectivity. This NHC-catalyzed annulation has been used for the total synthesis of maremycin B.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.