ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2012
The 5-HTTLPR polymorphism moderates the effect of stressful life events on drinking behavior in college students of African descent.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Ondansetron reduces naturalistic drinking in nontreatment-seeking alcohol-dependent individuals with the LL 5'-HTTLPR genotype: a laboratory study.Alcoholism, clinical and experimental research · 2014Trial
- Racial/ethnic discrimination, ADH1B*3, and coping-motivated drinking among Black college students.The American journal on addictions · 2022Article
- Phased Haplotype Resolution of theGenes · 2020Article
- Interaction Between the 5-Hydroxytryptamine Transporter-Linked Polymorphic Region (5-HTTLPR) and Negative Life Events in Adolescent Heavy Drinking.Journal of studies on alcohol and drugs · 2020Article
- Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use.Journal of youth and adolescence · 2020Article
- The moderating effect of FKBP5 and 5-HTTLPR polymorphisms on the day-level association between drinking to cope motivation and negative affect.Psychiatry research · 2020Article
- Racial discrimination, binge drinking, and negative drinking consequences among black college students: serial mediation by depressive symptoms and coping motives.Ethnicity & health · 2019Article
- Interaction Effects between the Cumulative Genetic Score and Psychosocial Stressor on Self-Reported Drinking Urge and Implicit Attentional Bias for Alcohol: A Human Laboratory Study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Article
- Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic events on trajectories of alcohol use disorder symptoms among African American college students.Development and psychopathology · 2018Article
- A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.The American journal on addictions · 2018Review
- Interaction between the ADH1B*3 allele and drinking motives on alcohol use among Black college students.The American journal of drug and alcohol abuse · 2018Article
- Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What's Next?Frontiers in psychology · 2018Article
- Review: Environmental influences on alcohol use: Informing research on the joint effects of genes and the environment in diverse U.S. populations.The American journal on addictions · 2017Review
- Genetic Polymorphism in the Promoter Region of Serotonin Transporter: Implications for Ethanol Abuse in Children and Adolescents.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2016Article
- Drinking to cope among African American college students: an assessment of episode-specific motives.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2014Article
- Framing ethnic variations in alcohol outcomes from biological pathways to neighborhood context.Alcoholism, clinical and experimental research · 2014Review
- A mediational model of racial discrimination and alcohol-related problems among african american college students.Journal of studies on alcohol and drugs · 2014Article
- Transient increase in alcohol self-administration following a period of chronic exposure to corticosterone.Neuropharmacology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Covault et al. [Covault et al. (2007); Biol Psychiatry 61(5): 609-616] reported that the common functional polymorphism, 5-HTTLPR, in the serotonin transporter gene moderated the association between past-year stressful events and daily reports of drinking in a sample of European-American (EA) college students. We examined this effect in college students of African descent. Students recruited at a Historically Black University (n = 564) completed web-based measures of past-year stressful life experiences and daily reports of drinking and heavy drinking over a 30-day period. Participants were genotyped for the tri-allelic 5-HTTLPR polymorphism and dichotomized as low-activity S' allele carriers or high-activity L' homozygotes. Generalized linear models were used to examine the effects of life stress, genotype, and their interaction on the two drinking measures. In students who completed 15 or more daily surveys (n = 393), there was a significant interaction of past-year stressful events, 5-HTTLPR genotype, and gender on the number of drinking days (P = 0.002). Similar findings were obtained in relation to heavy drinking days (P = 0.007). Men showed a main effect of past-year stressful events on both drinking outcomes (P's < 0.001), but no main or moderator effects of genotype. In women, the S' allele moderated the impact of past-year life stressors on the frequency of drinking and heavy drinking days (P's < 0.001). In college students of African descent, past-year stressful events were associated with more frequent drinking and heavy drinking, an effect that was moderated by the 5-HTTLPR polymorphism. However, in contrast to the findings in EA students, in the current sample, 5-HTTLPR moderated the association only among women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.