ArticleInflammatory bowel diseases2012
Plasmablast frequency and trafficking receptor expression are altered in pediatric ulcerative colitis.
Article in Inflammatory bowel diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Immune-microbe interactions in pediatric ulcerative colitis: clinical features, pathogenesis, and novel targeted therapeutic strategies.Frontiers in immunology · 2026Review
- Clonal expansion and markers of directed mutation of IGHV4-34 B cells in plasmablasts during Kawasaki disease.Molecular immunology · 2022Article
- Article
- Inherent Immune Cell Variation Within Colonic Segments Presents Challenges for Clinical Trial Design.Journal of Crohn's & colitis · 2020Article
- Antibodies and Immunity During Kawasaki Disease.Frontiers in cardiovascular medicine · 2020Review
- An autopsy case of acute myocarditis with unique lymph node findings characterized by the proliferation of reactive plasmablasts.Journal of clinical and experimental hematopathology : JCEH · 2020Article
- B Cells and Antibodies in Kawasaki Disease.International journal of molecular sciences · 2019Review
- Function and dysfunction of plasma cells in intestine.Cell & bioscience · 2019Review
- Oral cholera vaccination promotes homing of IgAMucosal immunology · 2018Article
- Suppressed plasmablast responses in febrile infants, including children with Kawasaki disease.PloS one · 2018Article
- Trafficking receptor signatures define blood plasmablasts responding to tissue-specific immune challenge.JCI insight · 2017Article
- B-cell populations discriminate between pediatric- and adult-onset multiple sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2017Article
- Circulating memory B cells and plasmablasts are associated with the levels of serum immunoglobulin in patients with ulcerative colitis.Journal of cellular and molecular medicine · 2016Article
- Leukocyte Trafficking to the Small Intestine and Colon.Gastroenterology · 2016Review
- Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations.Annals of the rheumatic diseases · 2015Article
- Expansion of CD27high plasmablasts in transverse myelitis patients that utilize VH4 and JH6 genes and undergo extensive somatic hypermutation.Genes and immunityArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe incidence of pediatric ulcerative colitis (UC), a chronic autoinflammatory disease of the colon, is on the rise. Although an increased infiltration of B cells from the peripheral blood into the colon occurs in UC, B-cell trafficking is understudied. We hypothesized that the frequency of circulating plasmablasts (PBs) and their trafficking receptor (TR) expression may be indicative of the location and degree of pathology in pediatric UC.
methodsWe conducted multicolor flow cytometry analyses of circulating IgA(+/-) PBs and IgA(+) memory B cells (MBCs) in pediatric UC patients with remission, mild, moderate, and severe state of disease (n = 12), and healthy pediatric (n = 2) and adult donors (n = 11).
resultsCompared to healthy donors the average frequency of PBs among total peripheral blood lymphocytes is increased 30-fold during severe UC activity, and positively correlates with Pediatric Ulcerative Colitis Activity Index score, C-reactive protein level, and erythrocyte sedimentation rate. A greater percent of PBs in severe patients express the gut-homing receptors α4β7 and CCR10, and the inflammatory homing molecule P-selectin ligand (P-sel lig). The percent of IgA(+) MBCs expressing α4β7, however, is reduced. Furthermore, expression of the small intestine TR CCR9 is decreased on α4β7(high) PBs, and on α4β7(high) /CCR10(high) PBs and MBCs in these patients, consistent with preferential cell targeting to the colon.
conclusionsPeripheral blood PBs with a colon-homing phenotype (α4β7/CCR10/P-sel lig) are elevated in children with severe UC. Screening this B-cell subset may provide a complementary approach in monitoring disease activity or therapeutic efficacy in pediatric UC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.