Evidence map›Paper›PMID 22488702›Full record

ReviewCancer2012

Weight management and its role in breast cancer rehabilitation.

Wendy Demark-Wahnefried, Kristin L Campbell, Sandra C Hayes

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07467824 (Impact of Prehabilitation With Exercise and Nutrition, and Comprehensive Follow-up in Women With Breast Cancer), which is not on this map. Cited by 110 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 9 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07467824 narecruitingnot on this mapstarted 2026, after this paper: background citation

Impact of Prehabilitation With Exercise and Nutrition, and Comprehensive Follow-up in Women With Breast Cancer: The PREACT Trial

TypeinterventionalSponsorEuropean University Miguel de CervantesRan2026 to 2029Enrolled66ConditionsBreast Cancer, Breast NeoplasmsArmsPrehabilitation: Exercise and nutrition
3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 9 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Leptin signaling in breast cancer and its crosstalk with peroxisome proliferator-activated receptors α and γ.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Pooled it
  3. Benefits of weight loss programs for breast cancer survivors: a systematic reviews and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  4. Pooled it
  5. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
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  7. Pooled it
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  9. Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies.Annals of oncology : official journal of the European Society for Medical Oncology · 2014
    Pooled it
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  19. Impact of a behavioral weight loss intervention on comorbidities in overweight and obese breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Wendy Demark-WahnefriedDepartment of Nutrition Sciences, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama 35294, USA. demark@uab.edu
Kristin L Campbell
Sandra C Hayes
Queensland University of Technology · AUUniversity of Alabama at Birmingham · USUniversity of British Columbia · CA

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MICHAEL JAMES BERTRAM · 1985 to 2026
$165.9M
NCI NIH HHS P30 CA013148NCI NIH HHS P30 CA014236NCI NIH HHS P30 CA13148-40
6 · The paper itself

Abstract

Overweight and obesity are risk factors for postmenopausal breast cancer, and many women diagnosed with breast cancer, irrespective of menopausal status, gain weight after diagnosis. Weight management plays an important role in rehabilitation and recovery because obesity and/or weight gain may lead to poorer breast cancer prognosis, as well as prevalent comorbid conditions (eg, cardiovascular disease and diabetes), poorer surgical outcomes (eg, increased operating and recovery times, higher infection rates, and poorer healing), lymphedema, fatigue, functional decline, and poorer health and overall quality of life. Health care professionals should encourage weight management at all phases of the cancer care continuum as a means to potentially avoid adverse sequelae and late effects, as well as to improve overall health and possibly survival. Comprehensive approaches that involve dietary and behavior modification, and increased aerobic and strength training exercise have shown promise in either preventing weight gain or promoting weight loss, reducing biomarkers associated with inflammation and comorbidity, and improving lifestyle behaviors, functional status, and quality of life in this high-risk patient population.

Indexed as

Life StyleWeight LossAgedAged, 80 and overAmerican Cancer SocietyBehavior TherapyBody Mass IndexBreast NeoplasmsComorbidityCongresses as TopicDiet, Fat-RestrictedExerciseFemaleHumansMiddle AgedObesity

Identifiers

PMID22488702
PMCPMC3812811
OpenAlexW1549646880

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.