Evidence map›Paper›PMID 22488458›Full record

ArticlePublic health genomics2012

Finding a place for genomics in health disparities research.

S M Fullerton, S Knerr, W Burke

Abstract read
In one paragraph

Article in Public health genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Race and prostate cancer: genomic landscape.Nature reviews. Urology · 2022
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Successful recruitment and retention of diverse participants in a genomics clinical trial: a good invitation to a great party.Genetics in medicine : official journal of the American College of Medical Genetics · 2019
    Article
  9. Population Epigenetics.Current opinion in systems biology · 2017
    Article
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

S M FullertonDepartment of Bioethics and Humanities, and Center for Genomics and Healthcare Equality, University of Washington, Seattle, WA 98195, USA. smfllrtn@uw.edu
S Knerr
W Burke

Funding

Genomic Health Care and the Medically UnderservedP50HG003374 · NHGRI · UNIVERSITY OF WASHINGTON · PI BURKE, WYLIE G. · 2004 to 2014
$9.8M
Understanding and preventing breast cancer disparties in LatinasP50CA148143 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI THOMPSON, BETI · 2010 to 2016
$9.7M
Biobehavioral Cancer Prevention and Control Training ProgramR25CA092408 · NCI · UNIVERSITY OF WASHINGTON · PI PATRICK, DONALD LEE · 2001 to 2015
$7.1M
NCI NIH HHS P50 CA148143NCI NIH HHS R25 CA092408NCI NIH HHS R25 CA92408NHGRI NIH HHS P50 HG003374
6 · The paper itself

Abstract

The existence of pronounced differences in health outcomes between US populations is a problem of moral significance and public health urgency. Pursuing research on genetic contributors to such disparities, despite striking data on the fundamental role of social factors, has been controversial. Still, advances in genomic science are providing an understanding of disease biology at a level of precision not previously possible. The potential for genomic strategies to help in addressing population-level disparities therefore needs to be carefully evaluated. Using 3 examples from current research, we argue that the best way to maximize the benefits of population-based genomic investigations, and mitigate potential harms, is to direct research away from the identification of genetic causes of disparities and instead focus on applying genomic methodologies to the development of clinical and public health tools with the potential to ameliorate healthcare inequities, direct population-level health interventions or inform public policy. Such a transformation will require close collaboration between transdisciplinary teams and community members as well as a reorientation of current research objectives to better align genomic discovery efforts with public health priorities and well-recognized barriers to fair health care delivery.

Indexed as

GenomicsHealthcare DisparitiesHealth Status DisparitiesAsthmaDelivery of Health CareDrug DesignGenome, HumanHealth Services AccessibilityHealth Services ResearchHealth StatusHumansInfant, NewbornKidney Failure, ChronicPremature BirthPublic Health

Identifiers

PMID22488458
PMCPMC3685214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.