ReviewSeminars in immunopathology2012
Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation.
Review in Seminars in immunopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Effect of vitamin D supplementation on N-glycan branching and cellular immunophenotypes in MS.Annals of clinical and translational neurology · 2020Trial
- N-glycosylation, a leading role in viral infection and immunity development.Molecular biology reports · 2022Review
- Distinct Glycosylation Responses to Spinal Cord Injury in Regenerative and Nonregenerative Models.Journal of proteome research · 2022Article
- Expression Profile of Immunoglobulin G Glycosylation in Children With Epilepsy in Han Nationality.Frontiers in molecular neuroscience · 2022Article
- GANAB as a Novel Biomarker in Multiple Sclerosis: Correlation with Neuroinflammation and IFI35.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Extracellular matrix protein N-glycosylation mediates immune self-tolerance inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Establishing Rules for Self-Adhesion and Aggregation ofLangmuir : the ACS journal of surfaces and colloids · 2020Article
- Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential.Biomedicines · 2020Article
- N-Glycan Branching Decouples B Cell Innate and Adaptive Immunity to Control Inflammatory Demyelination.iScience · 2020Article
- Vitamin D and Demyelinating Diseases: Neuromyelitis Optica (NMO) and Multiple Sclerosis (MS).Autoimmune diseases · 2020Review
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- Glycans as Key Checkpoints of T Cell Activity and Function.Frontiers in immunology · 2018Review
- Maturing Glycoproteomics Technologies Provide Unique Structural Insights into the N-glycoproteome and Its Regulation in Health and Disease.Molecular & cellular proteomics : MCP · 2016Review
- O-glycosylation sites identified from mucin core-1 type glycopeptides from human serum.Glycoconjugate journal · 2016Article
- Current strategies and findings in clinically relevant post-translational modification-specific proteomics.Expert review of proteomics · 2015Review
- N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca²⁺ signaling.Nature immunology · 2014Article
- Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms.Genes and immunity · 2014Article
- Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants.Journal of neuroimmunology · 2013Article
- Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes.Frontiers in molecular neuroscience · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Autoimmune diseases such as multiple sclerosis (MS) result from complex and poorly understood interactions of genetic and environmental factors. A central role for T cells in MS is supported by mouse models, association of the major histocompatibility complex region, and association of critical T cell growth regulator genes such as interleukin-2 receptor (IL-2RA) and interleukin-7 receptor (IL-7RA). Multiple environmental factors (vitamin D(3) deficiency and metabolism) converge with multiple genetic variants (IL-7RA, IL-2RA, MGAT1, and CTLA-4) to dysregulate Golgi N-glycosylation in MS, resulting in T cell hyperactivity, loss of self-tolerance and in mice, a spontaneous MS-like disease with neurodegeneration. Here, we review the genetic and biological interactions that regulate MS pathogenesis through dysregulation of N-glycosylation and how this may enable individualized therapeutic approaches.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.