Evidence map›Paper›PMID 22488247›Full record

ArticleImmunogenetics2012

Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC.

Martin F Flajnik, Tereza Tlapakova, Michael F Criscitiello, Vladimir Krylov, Yuko Ohta

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. NKp30: A Key Membrane Molecule in the Fight Against Cancer and Infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Martin F FlajnikDepartment of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA.
Tereza Tlapakova
Michael F Criscitiello
Vladimir Krylov
Yuko Ohta
Charles University · CZUniversity of Maryland, Baltimore · USTexas A&M University · US

Funding

EVOLUTION OF THE MAJOR HISTOCOMPATIBILITY COMPLEXR01RR006603 · NCRR · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FLAJNIK, MARTIN F · 1991 to 2011
$3.4M
ONTOGENY AND PHYLOGENY OF THE MHCR01AI027877 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI FLAJNIK, MARTIN F · 1995 to 2009
$3.2M
NCRR NIH HHS R01 RR006603NCRR NIH HHS RR006603NIAID NIH HHS AI02877NIAID NIH HHS R01 AI027877
6 · The paper itself

Abstract

The B7 family of genes is essential in the regulation of the adaptive immune system. Most B7 family members contain both variable (V)- and constant (C)-type domains of the immunoglobulin superfamily (IgSF). Through in silico screening of the Xenopus genome and subsequent phylogenetic analysis, we found novel genes belonging to the B7 family, one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. The B7H6 expression patterns also varied in a species-specific manner. Human B7H6 binds to the activating natural killer receptor, NKp30. While the NKp30 gene is single-copy and maps to the MHC in most vertebrates, many Xenopus NKp30 genes were found in a cluster on a separate chromosome that does not harbor the MHC. Indeed, in all species so far analyzed from sharks to mammals, the number of NKp30 and B7H6 genes correlates well, suggestive of receptor-ligand co-evolution. Furthermore, we identified a Xenopus-specific B7 homolog (B7HXen) and revealed its close linkage to B2M, which we have demonstrated previously to have been originally encoded in the MHC. Thus, our study provides further proof that the B7 precursor was included in the proto MHC. Additionally, the comparative analysis revealed a new B7 family member, B7H7, which was previously designated in the literature as an unknown gene, HHLA2.

Indexed as

Amino Acid SequenceAnimalsB7 AntigensEvolution, MolecularGenetic LinkageHumansImmunoglobulinsNatural Cytotoxicity Triggering Receptor 3PhylogenySequence AlignmentSpecies SpecificityXenopusB7 AntigensHHLA2 protein, humanImmunoglobulinsNatural Cytotoxicity Triggering Receptor 3NCR3LG1 protein, humanNCR3 protein, human

Identifiers

PMID22488247
PMCPMC3709836
OpenAlexW2130366224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.