ArticleHistochemistry and cell biology2012
Exercise-induced muscle damage and inflammation: re-evaluation by proteomics.
Article in Histochemistry and cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Tart cherry supplementation causes differential regulation of skeletal muscle proteome after eccentric exercise.Frontiers in nutrition · 2026Trial
- Effect of Resonant Frequency Vibration on Delayed Onset Muscle Soreness and Resulting Stiffness as Measured by Shear-Wave Elastography.International journal of environmental research and public health · 2021Trial
- The effects of a multi-ingredient supplement on markers of muscle damage and inflammation following downhill running in females.Journal of the International Society of Sports Nutrition · 2016Trial
- Re-evaluation of sarcolemma injury and muscle swelling in human skeletal muscles after eccentric exercise.PloS one · 2013Trial
- Systemic Integrative Mechanisms and Intervention Strategies in Exercise-Induced Skeletal Muscle Damage: Evidence from Animal, Clinical, and Multi-Omics Studies.International journal of molecular sciences · 2026Review
- Resistance exercise-induced circulating factors influence the damaged skeletal muscle proteome in a sex-dependent manner.Physiological reports · 2025Article
- Exercise-Induced Muscle Damage and Protein Intake: A Bibliometric and Visual Analysis.Nutrients · 2022Review
- The effects of cocoa flavanols on indices of muscle recovery and exercise performance: a narrative review.BMC sports science, medicine & rehabilitation · 2021Review
- Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics.Proteomes · 2019Review
- Eccentric Muscle Contractions: Risks and Benefits.Frontiers in physiology · 2019Review
- AIIMDs: An Integrated Framework of Automatic Idiopathic Inflammatory Myopathy Diagnosis for Muscle.IEEE journal of biomedical and health informatics · 2018Article
- Muscle Injuries in Sports: A New Evidence-Informed and Expert Consensus-Based Classification with Clinical Application.Sports medicine (Auckland, N.Z.) · 2017Article
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- Article
- Review
- AUTOMATIC MUSCLE PERIMYSIUM ANNOTATION USING DEEP CONVOLUTIONAL NEURAL NETWORK.Proceedings. IEEE International Symposium on Biomedical Imaging · 2015Article
- The impact of a pre-loaded multi-ingredient performance supplement on muscle soreness and performance following downhill running.Journal of the International Society of Sports Nutrition · 2015Article
- The effects PCSO-524®, a patented marine oil lipid and omega-3 PUFA blend derived from the New Zealand green lipped mussel (Perna canaliculus), on indirect markers of muscle damage and inflammation after muscle damaging exercise in untrained men: a randomized, placebo controlled trial.Journal of the International Society of Sports Nutrition · 2015Article
- Acute resistance exercise increases the expression of chemotactic factors within skeletal muscle.European journal of applied physiology · 2014Article
- Systemic cytokine response to three bouts of eccentric exercise.Results in immunology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using proteomics combined with immunohistochemistry (IHC), we re-evaluated our previous hypothesis that voluntary eccentric exercise does not result in inflammation or necrosis while it does lead to muscular adaptation/remodeling through Z-band related proteins. Muscle biopsies from m. vastus lateralis were taken from five control and five exercised subjects 48 h after 45 min of downhill running. General muscle morphology was examined using histology and histochemistry. Proteomics was used to reveal protein profiles and novel proteins. IHC with specific antibody against three Z-band related proteins identified by proteomics was also performed. General morphology showed no muscle degeneration or inflammation in any exercised biopsy. Proteomics revealed that out of 612 individual protein spots, the exercised biopsy presented three proteins with significant (p < 0.05) higher expression ratio and four proteins of lower ratio compared to controls. Four of the proteins desmin, actin, Rab-35 and LDB3 are Z-band related; the former two have long been the focus of interest and were found to be up-regulated in the study; the latter two are Z-band assembly/stabilization protein and were for the first time observed to be down-regulated in exercised muscles. The other three proteins are related with either cellular metabolism or calcium homeostasis and none is related with muscle necrosis or inflammation. IHC observations that both desmin and actin were increased whereas LDB3 was completely absent in some focal areas are consistent with proteomic results and with our previous observations. The results of the study confirmed our previous findings and therefore strengthened the hypothesis that voluntary eccentric exercise does not cause human muscle necrosis or inflammation; instead, muscular remodeling occurs specifically through Z-band related proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.