ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Inflammation induced by phytomodulatory proteins from the latex of Calotropis procera (Asclepiadaceae) protects against Salmonella infection in a murine model of typhoid fever.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Novel yeasts with potential probiotic characteristics isolated from the endogenous ferment of artisanal Minas cheese.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Latex proteins downregulate inflammation and restores blood-coagulation homeostasis in acute Salmonella infection.Memorias do Instituto Oswaldo Cruz · 2020Article
- Erythrocytes morphology and hemorheology in severe bacterial infection.Memorias do Instituto Oswaldo Cruz · 2019Article
- Cytotoxicity against tumor cell lines and anti-inflammatory properties of chitinases from Calotropis procera latex.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Wound healing modulation by a latex protein-containing polyvinyl alcohol biomembrane.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Peptidases from latex of Carica candamarcensis upregulate COX-2 and IL-1 mRNA transcripts against Salmonella enterica ser. Typhimurium-mediated inflammation.Mediators of inflammation · 2014Article
- Protein fraction of Calotropis procera latex protects against 5-fluorouracil-induced oral mucositis associated with downregulation of pivotal pro-inflammatory mediators.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- Using Molecular Docking Analysis to DiscoveryPharmacognosy magazineArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designLaticifer proteins (LP) of Calotropis procera were fractionated by ion-exchange chromatography, and the influence of a sub-fraction (LP(PI)) on the inflammatory response of Swiss mice challenged by Salmonella enterica Ser. Typhimurium was investigated.
methodsMice (n = 10) received LP(PI) (30 or 60 mg/kg) in a single inoculum by the intraperitoneal route 24 h before infection. To investigate the relevance of the proteolytic activity, three additional groups were included: the first one received heat-treated LP (30 mg/kg-30 min at 100 °C), the second received LP (30 mg/kg) inactivated by iodoacetamide, and a control group received only phosphate-buffered saline (PBS).
resultsThe survival rate reached 100 % in mice treated with LP(PI) and was also observed with the other treatment, whereas the PBS group died 1-3 days after infection. The neutrophil infiltration into the peritoneal cavity of pretreated mice was enhanced and accompanied by high bacterial clearance from the bloodstream. Tumor necrosis factor-alpha mRNA transcripts, but not interferon-gamma, were detected early in spleen cells of pretreated mice after infection; however, the nitric oxide contents in the bloodstream were decreased in comparison to the PBS group.
conclusionsThe inflammatory stimulus of C. procera proteins increased phagocytosis and balanced the nitric oxide release in the bloodstream, preventing septic shock induced by Salmonella infection.
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