Evidence map›Paper›PMID 22487654›Full record

ReviewNature reviews. Immunology2012

Fine-tuning of dendritic cell biology by the TNF superfamily.

Leslie Summers deLuca, Jennifer L Gommerman

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. The Biology of Dendritic Cells: In Health and Disease.Advances in experimental medicine and biology · 2025
    Review
  10. Long non-coding RNAeLife · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Impaired Proliferation of CD8Journal of immunology research · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Leslie Summers deLucaUniversity of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
Jennifer L Gommerman

Funding

Canadian Institutes of Health Research MOP 67157
6 · The paper itself

Abstract

Members of the tumour necrosis factor (TNF) superfamily have been implicated in a wide range of biological functions, and their expression by cells of the immune system makes them appealing targets for immunomodulation. One common theme for TNF superfamily members is their coordinated expression at the interface between antigen-specific T cells and antigen-presenting dendritic cells and, by virtue of this expression pattern, TNF superfamily members can shape T cell immune responses. Understanding how to manipulate such functions of the TNF superfamily may allow us to tip the balance between immunity and tolerance in the context of human disease.

Indexed as

AnimalsDendritic CellsHumansInflammationLymphoid TissueNeoplasmsTumor Necrosis Factor InhibitorsTumor Necrosis FactorsTumor Necrosis Factor InhibitorsTumor Necrosis Factors

Identifiers

PMID22487654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.