ArticlePancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
TNF-alpha gene (TNFA) variants increase risk for multi-organ dysfunction syndrome (MODS) in acute pancreatitis.
Article in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Meta-analysis and field synopsis of genetic variants associated with the risk and severity of acute pancreatitis.BJS open · 2020Pooled it
- Efficacy of blood purification for severe pancreatitis and acute respiratory distress syndrome.Medicine · 2019Pooled it
- Article
- Potential influence of gut microbiota on the process of hypertriglyceridemia-aggravated acute pancreatitis.World journal of gastroenterology · 2026Review
- Whole exome sequencing reveals aniMetaOmics · 2025Article
- Fire in the belly: A scoping review of the immunopathological mechanisms of acute pancreatitis.Frontiers in immunology · 2022Article
- Blockade of JAK2 signaling produces immunomodulatory effect to preserve pancreatic homeostasis in severe acute pancreatitis.Biochemistry and biophysics reports · 2021Article
- Curcumin protects the pancreas from acute pancreatitis via the mitogen‑activated protein kinase signaling pathway.Molecular medicine reports · 2019Article
- Organ Failure Due to Systemic Injury in Acute Pancreatitis.Gastroenterology · 2019Review
- Condemned or Not to Die? Gene Polymorphisms Associated With Cell Death in Pemphigus Foliaceus.Frontiers in immunology · 2019Article
- Association of a genetic polymorphism of IL1RN with risk of acute pancreatitis in a Korean ethnic group.The Korean journal of internal medicine · 2018Article
- The -251 A/T Polymorphism in the IL8 Promoter is a Risk Factor for Acute Pancreatitis.Pancreas · 2018Article
- Murine genotype impacts pancreatitis severity and systemic inflammation: An experimental study.Annals of medicine and surgery (2012) · 2017Article
- Protective effects of heme oxygenase-1 against severe acute pancreatitis via inhibition of tumor necrosis factor-α and augmentation of interleukin-10.BMC gastroenterology · 2017Article
- Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis.Gastroenterology research and practice · 2017Review
- Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis.The American journal of gastroenterology · 2015Observational
- Cytokine gene associations with self-report ratings of morning and evening fatigue in oncology patients and their family caregivers.Biological research for nursing · 2015Article
- Genetics and treatment options for recurrent acute and chronic pancreatitis.Current treatment options in gastroenterology · 2014Article
- Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis.Journal of Zhejiang University. Science. B · 2014Article
- Relationship between early inflammatory response and clinical evolution of the severe multiorgan failure in mechanical circulatory support-treated patients.Mediators of inflammation · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND/
objectivesAcute pancreatitis (AP) is a complex inflammatory syndrome with unpredictable progression to systemic inflammation and multi-organ dysfunction syndrome (MODS). Tumor necrosis factor alpha (TNF-α) is a cytokine that may link inflammation to the systemic inflammatory response syndrome (SIRS), which usually precedes MODS. Small genetic cohort studies of the TNFA promoter in AP produced ambiguous results. We performed a comprehensive evaluation of TNFA promoter variants to assess both susceptibility to AP and risk of progression to MODS.
methodsWe prospectively ascertained 401 controls and 211 patients with AP that were assessed for persistent SIRS (>48 h) and MODS. MODS was defined as failure of ≥2 organ systems (cardiovascular, pulmonary, and/or renal) persisting more than 48 h. Subjects were genotyped by DNA sequencing and analyzed for SNPs at -1031 C/T (rs1799964), -863 A/C (rs1800630), -857 C/T (rs1799724), -308 A/G (rs1800629), and -238 A/G (rs361525).
resultsTwenty-three of 211 AP patients (11%) developed MODS. TNFA promoter variants were not associated with susceptibility to AP, but progression to MODS was associated with the minor allele at -1031C (56.5% vs. 32.4% P = 0.022, OR: 2.7; 95%CI: 1.12-6.51) and -863A (43.5% vs. 21.8% P = 0.022, OR: 2.76; 95%CI: 1.12-6.74).
conclusionTNFA promoter variants do not alter susceptibility to AP, but rather the TNF-α expression-enhancing -1031C and -863A alleles significantly increased the risk of AP progression to MODS. These data, within the context of previous studies, clarify the risk of specific genetic variants in TNFA and therefore the role of TNF-α in the overall AP syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.