ArticleThe FEBS journal2012
A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2.
Article in The FEBS journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Requirements for the biogenesis of [2Fe-2S] proteins in the human and yeast cytosol.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unraveling the mechanism of [4Fe-4S] cluster assembly on the N-terminal cluster binding site of NUBP1.Protein science : a publication of the Protein Society · 2023Article
- In Cellulo Mössbauer and EPR Studies Bring New Evidence to the Long-Standing Debate on Iron-Sulfur Cluster Binding in Human Anamorsin.Angewandte Chemie (International ed. in English) · 2021Article
- EPR studies of wild type and mutant Dre2 identify essential [2Fe--2S] and [4Fe--4S] clusters and their cysteine ligands.Journal of biochemistry · 2017Article
- DNA replication inhibitor hydroxyurea alters Fe-S centers by producing reactive oxygen species in vivo.Scientific reports · 2016Article
- Epigenetic role for the conserved Fe-S cluster biogenesis protein AtDRE2 in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Anamorsin, a novel caspase-3 substrate in neurodegeneration.The Journal of biological chemistry · 2014Article
- Protein oxidation in the intermembrane space of mitochondria is substrate-specific rather than general.Microbial cell (Graz, Austria) · 2014Article
- Evolution of the cytosolic iron-sulfur cluster assembly machinery in Blastocystis species and other microbial eukaryotes.Eukaryotic cell · 2014Article
- Human anamorsin binds [2Fe-2S] clusters with unique electronic properties.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2013Article
- Molecular view of an electron transfer process essential for iron-sulfur protein biogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
Yeast Dre2 is an essential Fe-S cluster-containing protein that has been implicated in cytosolic Fe-S protein biogenesis and in cell death regulation in response to oxidative stress. Its absence in yeast can be complemented by the human homologous antiapoptotic protein cytokine-induced apoptosis inhibitor 1 (also known as anamorsin), suggesting at least one common function. Using complementary techniques, we have investigated the biochemical and biophysical properties of Dre2. We show that it contains an N-terminal domain whose structure in solution consists of a stable well-structured monomer with an overall typical S-adenosylmethionine methyltransferase fold lacking two α-helices and a β-strand. The highly conserved C-terminus of Dre2, containing two Fe-S clusters, influences the flexibility of the N-terminal domain. We discuss the hypotheses that the activity of the N-terminal domain could be modulated by the redox activity of Fe-S clusters containing the C-terminus domain in vivo.
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