ArticleBehavioural brain research2012
Pharmacological enhancement of calcium-activated potassium channel function reduces the effects of repeated stress on fear memory.
Article in Behavioural brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Neuronal plasticity in hippocampal neurons due to chronic mild stress and after stress removal in postnatal chicks.Journal of anatomy · 2024Article
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- The neural, behavioral, and epidemiological underpinnings of comorbid alcohol use disorder and post-traumatic stress disorder.International review of neurobiology · 2021Article
- Disruptive effects of repeated stress on basolateral amygdala neurons and fear behavior across the estrous cycle in rats.Scientific reports · 2019Article
- Chronic Stress Causes Projection-Specific Adaptation of Amygdala Neurons via Small-Conductance Calcium-Activated Potassium Channel Downregulation.Biological psychiatry · 2019Article
- Susceptibility and Resilience to Posttraumatic Stress Disorder-like Behaviors in Inbred Mice.Biological psychiatry · 2017Article
- Effects of Repeated Stress on Age-Dependent GABAergic Regulation of the Lateral Nucleus of the Amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Article
- Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Postsynaptic adenosine A2A receptors modulate intrinsic excitability of pyramidal cells in the rat basolateral amygdala.The international journal of neuropsychopharmacology · 2015Article
- Distinct effects of repeated restraint stress on basolateral amygdala neuronal membrane properties in resilient adolescent and adult rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Modulating fear extinction memory by manipulating SK potassium channels in the infralimbic cortex.Frontiers in behavioral neuroscience · 2014Article
- The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases.Expert opinion on therapeutic targets · 2013Review
- Differential effects of acute and repeated stress on hippocampus and amygdala inputs to the nucleus accumbens shell.The international journal of neuropsychopharmacology · 2013Article
- Repeated restraint stress exerts different impact on structure of neurons in the lateral and basal nuclei of the amygdala.Neuroscience · 2013Article
- Effects of repeated stress on excitatory drive of basal amygdala neurons in vivo.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Repeated restraint stress enhances cue-elicited conditioned freezing and impairs acquisition of extinction in an age-dependent manner.Behavioural brain research · 2013Article
- Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets.Journal of cardiovascular pharmacology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Repeated stress impacts emotion, and can induce mood and anxiety disorders. These disorders are characterized by imbalance of emotional responses. The amygdala is fundamental in expression of emotion, and is hyperactive in many patients with mood or anxiety disorders. Stress also leads to hyperactivity of the amygdala in humans. In rodent studies, repeated stress causes hyperactivity of the amygdala, and increases fear conditioning behavior that is mediated by the basolateral amygdala (BLA). Calcium-activated potassium (K(Ca)) channels regulate BLA neuronal activity, and evidence suggests reduced small conductance K(Ca) (SK) channel function in male rats exposed to repeated stress. Pharmacological enhancement of SK channels reverses the BLA neuronal hyperexcitability caused by repeated stress. However, it is not known if pharmacological targeting of SK channels can repair the effects of repeated stress on amygdala-dependent behaviors. The purpose of this study was to test whether enhancement of SK channel function reverses the effects of repeated restraint on BLA-dependent auditory fear conditioning. We found that repeated restraint stress increased the expression of cued conditioned fear in male rats. However, 1-Ethyl-2-benzimidazolinone (1-EBIO, 1 or 10 mg/kg) or CyPPA (5 mg/kg) administered 30 min prior to testing of fear expression brought conditioned freezing to control levels, with little impact on fear expression in control handled rats. These results demonstrate that enhancement of SK channel function can reduce the abnormalities of BLA-dependent fear memory caused by repeated stress. Furthermore, this indicates that pharmacological targeting of SK channels may provide a novel target for alleviation of psychiatric symptoms associated with amygdala hyperactivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.